Abstract: Alkaloid lappaconitine (I) and its derivatives -N(20)-deethyllappaconitine (II) and 5'-bromolappaconitine (III) in the base form and as salts - hydrochloride (I center dot HCl), hydrobromide (preparation allapinine) (I center dot HBr), hydrobromide (II center dot HBr), hydrobromide (III center dot HBr), succinate (I center dot Su) were taken for research of pharmacology activity. Moreover, pharmacology activity was investigated for a clathrates of lappaconitine - the bases, hydrochloride and hydrobromide with glycyrrhizic acid (IV) (I-IV; I center dot HCl-IV; I center dot HBr-IV). It is shown that, neither the base nor the salts, with the exception for hydrobromide, possess antiarrhythmic action on any of the models. Among glycyrrhizic acid clathrates, only the clathrate with hydrobromide of lappaconitine (I center dot HBr-IV) has a high activity on the two models of arrhythmia.

Cite: Tolstikova T.G. , Bryzgalov A.O. , Sorokina I.V. , Osadchii S.A. , Shults E.E. , Dolgikh M.P. , Khvostov M.V.
Solification with Hydrobromic Acid as a Factor Defining the Antiarrhythmic Effect of Lappaconitine Derivatives
Letters in Drug Design and Discovery. 2009. V.6. N7. P.475-477. DOI: 10.2174/157018009789108312 WOS Scopus

Dates:

Published print:

Oct 1, 2009

Identifiers:

Web of science	WOS:000271393000001
Scopus	2-s2.0-69449102953
OpenAlex	W1969794943

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