Antiulcer Activity of Preparations Containing Ultralow Doses of Antibodies in Modeled Chronic Ulcer in Rats

Antiulcer Activity of Preparations Containing Ultralow Doses of Antibodies in Modeled Chronic Ulcer in Rats Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2009, Volume: 148, Number: 3, Pages: 540-542 Pages count : DOI: 10.1007/s10517-010-0759-9

Tags

ultralow doses of antibodies; acetic acid-induced ulcer; regeneration; gastric mucosa

Authors

Tolstikova T. G. ¹ , Zhukova N. A. ¹ , Sorokina I. V. ¹ , Dolgikh M. P. ¹ , Ogorodnikova T. V. ¹ , Borodavkina M. V. ¹ , Dugina Yu. L. ¹ , Sergeeva S. A. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Div, NN Vorozhtsov Inst Organ Chem, Novosibirsk, Russia

Screening of three potential antiulcer preparations containing ultralow doses of antibodies to endogenous regulators of ulcer formation (gastrin, histamine, and H2 histamine receptors) on the model of acetic acid-induced gastric ulcer in rats revealed pronounced antiulcer effect of ultralow doses of antibodies to histamine. The dynamics of regeneration of the ulcer focus by morphological and histological characteristics was similar during treatment with ultralow doses of antibodies to histamine and with famotidine.

Tolstikova T.G. , Zhukova N.A. , Sorokina I.V. , Dolgikh M.P. , Ogorodnikova T.V. , Borodavkina M.V. , Dugina Y.L. , Sergeeva S.A.
Antiulcer Activity of Preparations Containing Ultralow Doses of Antibodies in Modeled Chronic Ulcer in Rats
Bulletin of Experimental Biology and Medicine. 2009. V.148. N3. P.540-542. DOI: 10.1007/s10517-010-0759-9 WOS Scopus РИНЦ

Published print:	Sep 1, 2009
Published online:	Feb 4, 2010

Web of science	WOS:000274696500049
Scopus	2-s2.0-77649191408
Elibrary	15311792
OpenAlex	W2000482372