Deaminated UV filter 3-hydroxykynurenine O-beta-D-glucoside is found in cataractous human lenses

Deaminated UV filter 3-hydroxykynurenine O-beta-D-glucoside is found in cataractous human lenses Full article

Journal

Experimental Eye Research
ISSN: 0014-4835 , E-ISSN: 1096-0007

Output data

Year: 2008, Volume: 86, Number: 6, Pages: 951-956 Pages count : 6 DOI: 10.1016/j.exer.2008.03.013

Tags

human lens; UV filters; cataract; protein modification; kynurenine

Authors

Snytnikova Olga A. ^1,2 , Fursova Anjella Zh. ³ , Chernyak Elena I. ⁴ , Vasiliev Vladimir G. ⁴ , Morozov Sergey V. ⁴ , Kolosova Nataliya G. ⁵ , Tsentalovich Yuri P. ¹

Affiliations

1	(Данные Web of science) SB RAS, Dept Multispin Coordinat Cpds, Int Tomog Ctr, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
3	(Данные Web of science) State Novosibirsk Reg Clin Hosp, Novosibirsk 630087, Russia
4	(Данные Web of science) SB RAS, Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia
5	(Данные Web of science) SB RAS, Inst Cytol & Genet, Novosibirsk 630090, Russia

Analysis of UV filter levels in 48 cataractous human lenses was performed with the use of HPLC. A new chromophore with the absorption maximum at 410 nm and molecular mass of 369 Da was detected and assigned as deaminated 3-hydroxykynurenine O-beta-D-glucoside (30HCKAG). Cataractous lenses are characterized by the wide range of the UV filter concentrations and remarkably lower levels of UV filters and glutathione than published for the normal lenses. No correlation between the lens age and the level of UV filters has been found in cataractous lenses. (c) 2008 Elsevier Ltd. All rights reserved.

Snytnikova O.A. , Fursova A.Z. , Chernyak E.I. , Vasiliev V.G. , Morozov S.V. , Kolosova N.G. , Tsentalovich Y.P.
Deaminated UV filter 3-hydroxykynurenine O-beta-D-glucoside is found in cataractous human lenses
Experimental Eye Research. 2008. V.86. N6. P.951-956. DOI: 10.1016/j.exer.2008.03.013 WOS Scopus

Published print:

Jun 1, 2008

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