Analgesic Properties of New Pyrrolidinomorphinane Derivatives: Revealing Potential Pathways

Analgesic Properties of New Pyrrolidinomorphinane Derivatives: Revealing Potential Pathways Full article

Journal

Natural Product Communications
ISSN: 1934-578X , E-ISSN: 1555-9475

Output data

Year: 2008, Volume: 3, Number: 10, Pages: 1621-1624 Pages count : 4

Tags

Pyrrolidinomorphinane derivatives; analgesic; naloxone; anti-inflammatory activity

Authors

Morozova Ekaterina A. ¹ , Tolstikova Tatiana G. ¹ , Bolkunov Alexey V. ¹ , Dolgikh Margarita P. ¹ , Shul'ts Elvira E. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Inst Organ Chem, Lab Pharmacol Res, Siberian Branch, Novosibirsk 630090, Russia

The pyrrolidinomorphinane derivatives have been found to be active in the writhing tests in mice with the analgesic effect being antagonized by naloxone. This suggests that analgesia is mediated by the opioid system. The compounds also displayed anti-inflammatory activity in formalin and histamine edema experimental models and the data may be evidence for antiinflammatory activity involvement in the inhibition of pain reaction.

Morozova E.A. , Tolstikova T.G. , Bolkunov A.V. , Dolgikh M.P. , Shul'ts E.E.
Analgesic Properties of New Pyrrolidinomorphinane Derivatives: Revealing Potential Pathways
Natural Product Communications. 2008. V.3. N10. P.1621-1624. WOS

Web of science

WOS:000260595800010