Cardiomyocyte count in rat myocardium under the effect of antitumor agents cyclophosphamide and triterpenoids

Cardiomyocyte count in rat myocardium under the effect of antitumor agents cyclophosphamide and triterpenoids Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2007, Volume: 144, Number: 3, Pages: 355-361 Pages count : 7 DOI: 10.1007/s10517-007-0332-3

Tags

cardiotoxicity; cyclophosphamide; betulonic acid and its amide; cardiomyocyte count

Authors

Lushnikova E.L. ¹ , Tolstikova T.G. ² , Nepomnyashchikh L.M. ¹ , Klinnikova M.G. ¹ , Molodykh O.P. ¹ , Sviridov E.A. ¹ , Sorokina I.V. ² , Zhukova N.A. ²

Affiliations

1	Laboratory of Cytology and Cellular Biology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk
2	Laboratory of Pharmacological Studies, N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk

Structural reorganization of the myocardium in response to antitumor agents (cyclophosphamide, betulonic acid and its amide) was studied. Cardiotoxic effects of these chemicals manifested in cardiomyocyte contracture and lytic injuries and by significant hemodynamic disorders. The most pronounced lytic and necrobiotic changes in cardiomyocytes were detected after injection of cyclophosphamide followed by betulonic amide; this led to a more pronounced decrease in heart weight as a result of a decrease in total cardiomyocyte count. Antitumor drugs differently changed the ratio of mono-to binuclear cardiomyocytes, which differ by their regeneratory and compensatory adaptive potential.

Lushnikova E.L. , Tolstikova T.G. , Nepomnyashchikh L.M. , Klinnikova M.G. , Molodykh O.P. , Sviridov E.A. , Sorokina I.V. , Zhukova N.A.
Cardiomyocyte count in rat myocardium under the effect of antitumor agents cyclophosphamide and triterpenoids
Bulletin of Experimental Biology and Medicine. 2007. V.144. N3. P.355-361. DOI: 10.1007/s10517-007-0332-3 WOS Scopus РИНЦ

Published print:

Sep 1, 2007

Web of science	WOS:000251865400025
Scopus	2-s2.0-37749046078
Elibrary	13548080
OpenAlex	W1972513892