Increase in pharmacological activity of drugs in their clathrates with plant glycosides

Increase in pharmacological activity of drugs in their clathrates with plant glycosides Full article

Journal

Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X

Output data

Year: 2007, Volume: 4, Number: 3, Pages: 168-170 Pages count : 3 DOI: 10.2174/157018007780077453

Tags

pharmacones clathration; nifedipine; glycyrrhizic acid; calcium channels

Authors

Tolstikova T.G. ¹ , Bryzgalov A.O. ¹ , Sorokina I.V. ¹ , Hvostov M.V. ¹ , Ratushnyak A.S. ² , Zapara T.A. ² , Simonova O.G. ²

Affiliations

1	(Данные Web of science) RAS, Novosibirsk NN Vorozhtsov Inst organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) RAS, Design Technol Inst Digital Tech, Siberian Branch, Novosibirsk 630090, Russia

The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.

Tolstikova T.G. , Bryzgalov A.O. , Sorokina I.V. , Hvostov M.V. , Ratushnyak A.S. , Zapara T.A. , Simonova O.G.
Increase in pharmacological activity of drugs in their clathrates with plant glycosides
Letters in Drug Design and Discovery. 2007. V.4. N3. P.168-170. DOI: 10.2174/157018007780077453 WOS Scopus

Published print:

Apr 1, 2007

Web of science	WOS:000244995900002
Scopus	2-s2.0-33947607995
OpenAlex	W2022588954