Photochemical and thermal reactivity of kynurenine

Photochemical and thermal reactivity of kynurenine Full article

Journal

Experimental Eye Research
ISSN: 0014-4835 , E-ISSN: 1096-0007

Output data

Year: 2006, Volume: 83, Number: 6, Pages: 1439-1445 Pages count : 7 DOI: 10.1016/j.exer.2006.07.022

Tags

kynurenine; cataract; deamination; kynurenine yellow; oxidation; alpha,beta-ketoalkene

Authors

Tsentalovich Yuri P. ¹ , Snytnikova Olga A. ¹ , Forbes Malcolm D.E. ² , Chernyak Elena I. ³ , Morozov Sergey V. ³

Affiliations

1	(Данные Web of science) Int Tomog Ctr, Dept Multispin Coordinast Cpds, Novosibirsk 630090, Russia
2	(Данные Web of science) Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
3	(Данные Web of science) Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia

The thermal and photochemical reactivity of kynurenine (KN), a tryptophan metabolite found in human lenses, has been studied in aqueous solution. The decarboxylation reaction of KN, resulting in the formation of 4-hydroxyquinoline, is reported for the first time. Rate constants for KN deamination and decarboxylation were determined in the temperature range 50-90 degrees C. The quantum yields for KN photodecomposition under argon were measured to be Phi(Ar) = (2.0 +/- 0.2) x 10(-5) and under oxygen (DO2 = (1-1 +/- 0.1) X 10(-4). (c) 2006 Elsevier Ltd. All rights reserved.

Tsentalovich Y.P. , Snytnikova O.A. , Forbes M.D.E. , Chernyak E.I. , Morozov S.V.
Photochemical and thermal reactivity of kynurenine
Experimental Eye Research. 2006. V.83. N6. P.1439-1445. DOI: 10.1016/j.exer.2006.07.022 WOS Scopus РИНЦ

Published print:

Dec 1, 2006

Web of science	WOS:000242300700017
Scopus	2-s2.0-33750438122
Elibrary	13510596
OpenAlex	W2093078654