Aryl alkyl ketones in a one-pot Gewald synthesis of 2-aminothiophenes

Aryl alkyl ketones in a one-pot Gewald synthesis of 2-aminothiophenes Full article

Journal

Synlett
ISSN: 0936-5214 , E-ISSN: 1437-2096

Output data

Year: 2006, Number: 16, Pages: 2559-2564 Pages count : 6 DOI: 10.1055/s-2006-951484

Tags

Gewald reaction; aryl alkyl ketones; 4-aryl-2-aminothiophene-3-carboxylates

Authors

Tormyshev Victor M. ¹ , Trukhin Dmitry V. ¹ , Rogozhnikova Olga Yu. ¹ , Mikhalina Tatiana V. ¹ , Troitskaya Tatiana I. ¹ , Flinn Anthony ²

Affiliations

1	(Данные Web of science) Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia
2	(Данные Web of science) Onyx Sci Ltd, Sunderland SR5 2TQ, Durham, England

2-Aminothiophene-3-carboxylates bearing various aryl groups at the 4-position are readily obtained in good to moderate yields by the one-pot Gewald reaction of aryl alkyl ketones with ethyl cyanoacetate and elemental sulfur in the presence of morpholinium acetate and excess morpholine.

Tormyshev V.M. , Trukhin D.V. , Rogozhnikova O.Y. , Mikhalina T.V. , Troitskaya T.I. , Flinn A.
Aryl alkyl ketones in a one-pot Gewald synthesis of 2-aminothiophenes
Synlett. 2006. N16. P.2559-2564. DOI: 10.1055/s-2006-951484 WOS Scopus РИНЦ

Published print:

Sep 1, 2006

Web of science	WOS:000241674100005
Scopus	2-s2.0-33750081476
Elibrary	13519653
OpenAlex	W2953272286