Improved synthesis of 1-hydroxy-2,2,5,5-tetramethyl-3-imidazoline 3-oxide (HTIO)

Improved synthesis of 1-hydroxy-2,2,5,5-tetramethyl-3-imidazoline 3-oxide (HTIO) Full article

Journal

Synthetic Communications
ISSN: 0039-7911 , E-ISSN: 1532-2432

Output data

Year: 2006, Volume: 36, Number: 19, Pages: 2763-2768 Pages count : 6 DOI: 10.1080/00397910600767272

Tags

aldonitrone; 2,2-dialkoxypropane; HTIO; 3-imidazoline 3-oxide; nitroxide

Authors

Polienko Julya F. ¹ , Schanding Thomas ² , Voinov Maxim A. ¹ , Grigor'ev Igor A. ¹

Affiliations

1	(Данные Web of science) Novosibirsk Organ Chem Inst, Novosibirsk, Russia
2	(Данные Web of science) Univ Kaiserslautern, Dept Chem, Kaiserslautern, Germany

A simple, efficient, mild, and reproducible method for the synthesis of 1-hydroxy-2,2,5,5-tetramethyl-3-imidazoline3-oxide is described. The method is based on the condensation of 2-hydroxyamino-2-methylpropanal oxime with 2,2-diethoxypropane in the presence of an equimolar quantity of acetic acid. Cost-effectiveness of the condensation procedure could be also achieved by replacing 2,2-diethoxypropane with less expensive 2,2-dimethoxypropane.

Polienko J.F. , Schanding T. , Voinov M.A. , Grigor'ev I.A.
Improved synthesis of 1-hydroxy-2,2,5,5-tetramethyl-3-imidazoline 3-oxide (HTIO)
Synthetic Communications. 2006. V.36. N19. P.2763-2768. DOI: 10.1080/00397910600767272 WOS Scopus РИНЦ

Published print:	Sep 1, 2006
Published online:	Feb 16, 2007

Web of science	WOS:000241196300002
Scopus	2-s2.0-33750080441
Elibrary	13525753
OpenAlex	W1986992670