Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma

Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2005, Volume: 140, Number: 3, Pages: 361-364 Pages count : 4 DOI: 10.1007/s10517-005-0490-0

Tags

polychemotherapy; liver; hepatoprotective effect; betulonic acid; [3-oxo20(29)-lttpene-28-oyl]-3-aininopropionic acid

Authors

Zhukova N.A. ¹ , Semenov D.E. ² , Sorokina I.V. ¹ , Tolstikova T.G. ¹ , Pozdnyakova S.V. ³ , Grek O.R. ³

Affiliations

1	(Данные Web of science) Russian Acad Sci, Lab Pharmacol Studies, NN Vorozhtsov Inst Organ Chem, Siberian Div, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Med Sci, Inst Reg Pathol & Pathomorphol, Siberian Div, Novosibirsk, Russia
3	(Данные Web of science) Novosibirsk State Med Acad, Novosibirsk, Russia

Morphological study of the effects of semisynthetic derivatives of betulin (betulonic acid and [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid) on the liver of CBA/Lac mice with transplanted RLS lymphoma was studied in the control and after cytostatic polychemotherapy. The number of small focal necroses decreased, while the counts of hepatocytes in a state of slight hyaline droplet degeneration increased. Morphometry of the main elements of liver parenchyma showed that alanine amide derivative of betulonic acid decreases the severity of necrotic and degenerative changes in the liver parenchyma, induced by cytostatic polychemotherapy. Betulonic acid exhibited no appreciable hepatoprotective effect under these conditions.

Zhukova N.A. , Semenov D.E. , Sorokina I.V. , Tolstikova T.G. , Pozdnyakova S.V. , Grek O.R.
Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma
Bulletin of Experimental Biology and Medicine. 2005. V.140. N3. P.361-364. DOI: 10.1007/s10517-005-0490-0 WOS Scopus РИНЦ

Жукова Н.А. , Семенов Д.Е. , Сорокина И.В. , Толстикова Т.Г. , Позднякова С.В. , Грек О.Р.
Влияние бетулоновой кислоты и ее производного [3-оксо-20(29)-лупен-28-оил]-3-аминопропионовой кислоты на структуру печени мышей с лимфомой RLS 348
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2005. Т.140. №9. С.348-351. РИНЦ

Published print:

Sep 1, 2005

Web of science	WOS:000234409200029
Scopus	2-s2.0-28844442881
Elibrary	13483489
OpenAlex	W2041757454