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The synthesis of new acyclic analogs of 3-phenacyluridine and comparative evaluation of their in vivo biological activity Full article

Journal Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353
Output data Year: 2020, Volume: 56, Number: 6, Pages: 769-775 Pages count : 7 DOI: 10.1007/s10593-020-02729-x
Tags 3-phenacyluridine; alkylation; biological activity; hypnotics; uridine receptor
Authors Novakov Ivan A. 1 , Brunilina Leila L. 1 , Kirillov Ivan A. 1 , Nawrozkij Maxim B. 1 , Robinovich Mariya D. 1,2 , Titova Evgeniya S. 1 , Sheikin Dmitry S. 1 , Ruchko Evsey A. 3 , Pavlova Alla, V 4 , Kotlyarova Anastasiya A. 4 , Tolstikova Tatyana G. 4
Affiliations
1 (Данные Web of science) Volgograd State Tech Univ, 28 Lenina Ave, Volgograd 400005, Russia
2 (Данные Web of science) JSC Volzhsky Orgsinthese, 100 Aleksandrova St, Volzhskiy 404117, Russia
3 (Данные Web of science) JSC Pharm Sintez, 2,Build 46 2nd Kabelnaya St, Moscow 111024, Russia
4 (Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Akad Lavrentieva Ave, Novosibirsk 630090, Russia

Abstract: New structural analogs of 3-phenacyluridine were obtained as a result of N(3)-alkylation of 1-(2-acetoxyethyl)- and 1-(2-acetoxyethoxymethyl)uracil. Biological studies of the title compounds in an acute in vivo experiment did not reveal their hypnotic properties and ability to enhance the effects of diazepam and chloral hydrate.
Cite: Novakov I.A. , Brunilina L.L. , Kirillov I.A. , Nawrozkij M.B. , Robinovich M.D. , Titova E.S. , Sheikin D.S. , Ruchko E.A. , Pavlova A.V. , Kotlyarova A.A. , Tolstikova T.G.
The synthesis of new acyclic analogs of 3-phenacyluridine and comparative evaluation of their in vivo biological activity
Chemistry of Heterocyclic Compounds. 2020. V.56. N6. P.769-775. DOI: 10.1007/s10593-020-02729-x WOS Scopus РИНЦ
Dates:
Published print: Jun 1, 2020
Published online: Jul 18, 2020
Identifiers:
Web of science WOS:000549786600005
Scopus 2-s2.0-85088151588
Elibrary 45410782
OpenAlex W3043020827
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