Biodegradable poly(L-lactide)/calcium phosphate composites with improved properties for orthopedics: Effect of filler and polymer crystallinity

Biodegradable poly(L-lactide)/calcium phosphate composites with improved properties for orthopedics: Effect of filler and polymer crystallinity Full article

Journal

Materials Science and Engineering: C
ISSN: 0928-4931 , E-ISSN: 1873-0191

Output data

Year: 2020, Volume: 112, Article number : 110813, Pages count : DOI: 10.1016/j.msec.2020.110813

Tags

Biodegradable polymers; Hydroxyapatite; Bone tissue engineering; Polylactide; Polymer composites

Authors

Demina Varvara A. ^1,2 , Krasheninnikov Sergei, V ¹ , Buzin Alexander, I ^1,2 , Kamyshinsky Roman A. ^1,3,4 , Sadovskaya Natalya, V ³ , Goncharov Evgeny N. ^5,6 , Zhukova Natalya A. ⁷ , Khvostov Mikhail, V ^7,8 , Pavlova Alla, V ⁷ , Tolstikova Tatjana G. ^7,8 , Sedush Nikita G. ^1,2 , Chvalun Sergei N. ^1,2

Affiliations

1	(Данные Web of science) Natl Res Ctr Kurchatov Inst, Pl Akad Kurchatova 1, Moscow 123098, Russia
2	(Данные Web of science) Russian Acad Sci, Enikolopov Inst Synthet Polymer Mat, Profsoyuznaya St 70, Moscow 117393, Russia
3	(Данные Web of science) Russian Acad Sci, Shubnikov Inst Crystallog Fed Sci Res Ctr Crystal, Leninskiy Prospect 59, Moscow 119333, Russia
4	(Данные Web of science) Moscow Inst Phys & Technol, Inst Sky Lane 9, Dolgoprudnyi 141700, Moscow Region, Russia
5	(Данные Web of science) RAS, Cent Clin Hosp, Fotieva St 10, Moscow 119333, Russia
6	(Данные Web of science) Russian Med Acad Continuous Profess Educ, Barrikadnaya St 2-1, Moscow 123995, Russia
7	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Lavrentiev Ave 9, Novosibirsk 630090, Russia
8	(Данные Web of science) Novosibirsk State Univ, Pirogova St 2, Novosibirsk 630090, Russia

Biodegradable poly(L-lactide)/calcium phosphate composites are promising materials for fabrication of bone fixation implants with improved properties. Multistage compounding was proposed as an efficient method for the preparation of biodegradable poly(L-lactide)/calcium phosphate composites with submicron filler dispersion and mechanical characteristics similar to native bone. The improvement of the characteristics is caused both by the filler itself and by the increase of polymer crystallinity due to the nucleation effect. The technique allows to fabricate biodegradable composites with controlled properties by varying concentration and type of the filler as well as degree of PLLA matrix crystallinity. Animal studies revealed that all the composites were biocompatible and non-toxic.

Demina V.A. , Krasheninnikov S.V. , Buzin A.I. , Kamyshinsky R.A. , Sadovskaya N.V. , Goncharov E.N. , Zhukova N.A. , Khvostov M.V. , Pavlova A.V. , Tolstikova T.G. , Sedush N.G. , Chvalun S.N.
Biodegradable poly(L-lactide)/calcium phosphate composites with improved properties for orthopedics: Effect of filler and polymer crystallinity
Materials Science and Engineering: C. 2020. V.112. 110813 . DOI: 10.1016/j.msec.2020.110813 WOS Scopus РИНЦ

Published print:

Jul 1, 2020

Web of science	WOS:000532843000041
Scopus	2-s2.0-85083000529
Elibrary	43281567
OpenAlex	W3009732933