Study of alkaloids of the Siberian and Altai flora 10. Synthesis of N(20)-deethyllappaconitine derivatives

Study of alkaloids of the Siberian and Altai flora 10. Synthesis of N(20)-deethyllappaconitine derivatives Full article

Journal

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Output data

Year: 2003, Volume: 52, Number: 11, Pages: 2490-2499 Pages count : DOI: 10.1023/B:RUCB.0000012375.59390.38

Tags

diterpenoid alkaloids; lappaconitine; N(20)-deethylation; N(20)-deethyllappaconitine derivatives; labeled lappaconitine

Authors

Pankrushina NA , Nikitina IA , Anferova NV , Osadchii SA , Shakirov MM , Shults EE , Tolstikov GA

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

Efficient procedures were developed for N-deethylation of lappaconitine to give N(20)-deethyllappaconitine. Alkyl derivatives of N(20)-deethyllappaconitine, including labeled lappaconitine, and N(20)-acetoxy-N(20)-deethyllappaconitine were prepared for the first time. The assignments of the signals for the carbon atoms in the C-13 NMR spectra of lappaconitine and related lappaconine were refined using C-13-C-13 2D INADEQUATE and 2D C-13-H-1 correlation experiments.

Pankrushina N. , Nikitina I. , Anferova N. , Osadchii S. , Shakirov M. , Shults E. , Tolstikov G.
Study of alkaloids of the Siberian and Altai flora 10. Synthesis of N(20)-deethyllappaconitine derivatives
Russian Chemical Bulletin. 2003. V.52. N11. P.2490-2499. DOI: 10.1023/B:RUCB.0000012375.59390.38 WOS Scopus РИНЦ

Published print:

Nov 1, 2003

Web of science	WOS:000188800800025
Scopus	2-s2.0-3543120663
Elibrary	13443998
OpenAlex	W2120995864