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New donors and acceptors of nitrogen oxide as potential therapeutic agents Full article

Journal Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620
Output data Year: 2003, Volume: 29, Number: 4, Pages: 395-401 Pages count : 7 DOI: 10.1023/A:1024913620825
Tags acceptors of nitrogen oxide; arterial pressure; donors of nitrogen oxide; nitronylnitroxyl radical; nitrogen oxide; vasodilators
Authors Yelinova V.I. 1 , Bobko A.A. 1 , Mazhukin D.G. 2 , Markel A.L. 3 , Khramtsov V.V. 1
Affiliations
1 (Данные Web of science) Russian Acad Sci, Inst Chem Kinet & Combust, Siberian Div, Novosibirsk 630090, Russia
2 (Данные Web of science) Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Div, Novosibirsk 630090, Russia
3 (Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Novosibirsk 630090, Russia

Abstract: The synthesis of new donors and acceptors of nitrogen oxide is described. New lipophilic nitronylnitroxyl radicals (NNR) that act as paramagnetic scavengers of nitrogen oxide are synthesized and characterized. The purity of the preparations is determined, and their structures are confirmed. The lipophilicity of the radicals is tested by ESR spectroscopy. The incorporation into lipid multilayers is shown to protect NNR from reduction in biological samples, while their ability to scavenge nitrogen oxide and form iminonitroxyl radicals is retained. A decreased rate of NNR reduction under these conditions substantially enhances their effectiveness as paramagnetic acceptors of nitrogen oxide in biological systems. The synthesis of a new hydrophilic NO donor. 3-bromo-3,4-dihydro-4,4-dimethyl-3-(2-pyridyl)-diazet-1,2-dioxide (DDpyr) is described. The constants of DDpyr decomposition in tris-HCl buffer (pH 7.5) and in DMSO are determined (4.5 x 10(-6) and 0.5 x 10(-6) s(-1). respectively). A substantially higher rate of DDpyr decomposition in buffer, compared with the decomposition rates determined previously for some diazetines, makes DDpyr a prospective candidate for the use in aqueous media. It is found in experiments on perfused rat caudal artery that DDpyr is an effective vasodilator. Intraperitoneal injection of DDpyr to hereditarily hypertensive rats (ISIAH line) at doses of 100-200 mug/kg body mass considerably diminishe their systolic arterial pressure.
Cite: Yelinova V.I. , Bobko A.A. , Mazhukin D.G. , Markel A.L. , Khramtsov V.V.
New donors and acceptors of nitrogen oxide as potential therapeutic agents
Russian Journal of Bioorganic Chemistry. 2003. V.29. N4. P.395-401. DOI: 10.1023/A:1024913620825 WOS Scopus РИНЦ
ArticleLinkType.TRANSLATED_TO_ORIGINAL: Елинова В.И. , Бобко А.А. , Мажукин Д.Г. , Маркель А.Л. , Храмцов В.В.
Новые доноры и акцепторы оксида азота как потенциальные терапевтические агенты
Биоорганическая химия (RUSS J BIOORG CHEM+). 2003. Т.29. №4. С.434-441. РИНЦ
Identifiers:
Web of science WOS:000185010300013
Scopus 2-s2.0-0042711021
Elibrary 13433856
OpenAlex W180880782
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