Abstract: The prostatotropic activity of glycyrrhizic acid disodium salt (Na(2)GA) was studied in the models of benign prostatic hyperplasia (BPH) induced by chronic injection of sulpiride (40 mg/kg intraperitoneally for 8 weeks) or testosterone propionate (20 mg/kg subcutaneously for 4 weeks) in the Wistar rats. The oral administration of Na(2)GA in a dose of 100 mg/kg produced a moderate antiproliferative effect in both BPH models resulting in reduced volume density of prostatic epithelium (in the testosterone model) and increased volume density of the glandular lumen (in both models). The observed prostatotropic effects of Na(2)GA were similar to those of Permixon and finasteride, but they were less pronounced as confirmed by smaller drops in epithelial volume density and epithelial-to-stromal ratio compared to the effects of both reference drugs.

Cite: Nizomov S.A. , Sorokina I.,.V. , Zhukova N.A. , Borisov S.A. , Tolstikova T.G. , Semenov D.E. , Bakarev M.A.
Prostatotropic Action of Glycyrrhizic Acid Disodium Salt in Benign Prostatic Hyperplasia Models
Bulletin of Experimental Biology and Medicine. 2020. V.169. N1. P.114-118. DOI: 10.1007/s10517-020-04836-3 WOS Scopus РИНЦ

ArticleLinkType.TRANSLATED_TO_ORIGINAL: Низомов С.А. , Сорокина И.В. , Жукова Н.А. , Борисов С.А. , Толстикова Т.Г. , Семенов Н.А. , Бакарев М.А.
Простатотропное действие динатриевой соли глицирризиновой кислоты при моделировании доброкачественной гиперплазии предстательной железы
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2020. Т.169. №1. С.124-129. РИНЦ

Dates:

Published print:	May 1, 2020
Published online:	Jun 2, 2020

Identifiers:

Web of science	WOS:000537387900007
Scopus	2-s2.0-85085882384
Elibrary	43305346
OpenAlex	W3032298908

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