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Human Serum Albumin Labelled with Sterically-Hindered Nitroxides as Potential MRI Contrast Agents Full article

Journal Molecules
, E-ISSN: 1420-3049
Output data Year: 2020, Volume: 25, Number: 7, Article number : 1709, Pages count : DOI: 10.3390/molecules25071709
Tags nitroxide radicals; spin probes; organic radical contrast agents; human serum albumin; homocysteine thiolactone; magnetic resonance imaging
Authors Dobrynin Sergey 1 , Kutseikin Sergei 2 , Morozov Denis 1 , Krumkacheva Olesya 3 , Spitsyna Anna 1 , Gatilov Yurii 1 , Silnikov Vladimir 2 , Angelovski Goran 4 , Bowman Michael K. 1,5 , Kirilyuk Igor 1 , Chubarov Alexey 2
Affiliations
1 (Данные Web of science) RAS, SB, NN Vorozhtsov Inst Organ Chem, Novosibirsk 630090, Russia
2 (Данные Web of science) RAS, SB, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia
3 (Данные Web of science) RAS, SB, Int Tomog Ctr, Novosibirsk 630090, Russia
4 (Данные Web of science) Max Planck Inst Biol Cybernet, D-72076 Tubingen, Germany
5 (Данные Web of science) Univ Alabama, Dept Chem & Biochem, Tuscaloosa, AL 35487 USA

Abstract: Four albumin-nitroxide conjugates were prepared and tested as metal-free organic radical contrast agents (ORCAs) for magnetic resonance imaging (MRI). Each human serum albumin (HSA) carrier bears multiple nitroxides conjugated via homocysteine thiolactones. These molecular conjugates retain important physical and biological properties of their HSA component, and the resistance of their nitroxide groups to bioreduction was retained or enhanced. The relaxivities are similar for these four conjugates and are much greater than those of their individual components: the HSA or the small nitroxide molecules. This new family of conjugates has excellent prospects for optimization as ORCAs.
Cite: Dobrynin S. , Kutseikin S. , Morozov D. , Krumkacheva O. , Spitsyna A. , Gatilov Y. , Silnikov V. , Angelovski G. , Bowman M.K. , Kirilyuk I. , Chubarov A.
Human Serum Albumin Labelled with Sterically-Hindered Nitroxides as Potential MRI Contrast Agents
Molecules. 2020. V.25. N7. 1709 . DOI: 10.3390/molecules25071709 WOS Scopus
Files: Full text from publisher
Dates:
Published online: Apr 8, 2020
Identifiers:
Web of science WOS:000531833400234
Scopus 2-s2.0-85083087817
OpenAlex W3015905096
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