Synthesis of 2-alkyl and 2-aryl pyrimidines from beta-chlorovinyl ketones of cyclopentanone type

Synthesis of 2-alkyl and 2-aryl pyrimidines from beta-chlorovinyl ketones of cyclopentanone type Full article

Journal

Synthetic Communications
ISSN: 0039-7911 , E-ISSN: 1532-2432

Output data

Year: 2001, Volume: 31, Number: 2, Pages: 233-243 Pages count : DOI: 10.1081/SCC-100000204

Authors

Popov SA , Tkachev AV

Affiliations

1	(Данные Web of science) Novosibirsk State Univ, Dept Nat Sci, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia

Amidines react in the presence of NaHCO3 with beta -chlorovinyl ketones, prepared regioselectively by the reaction off 2-acetylcyclopentanone-type diketones with PPh3-CCl4 in 73-78% yield, to afford 2-alkyl (aryl)-pyrimidines annelated with cyclopentane derivatives in 79-87% yields.

Popov S. , Tkachev A.
Synthesis of 2-alkyl and 2-aryl pyrimidines from beta-chlorovinyl ketones of cyclopentanone type
Synthetic Communications. 2001. V.31. N2. P.233-243. DOI: 10.1081/SCC-100000204 WOS Scopus

Published print:	Jan 1, 2001
Published online:	Aug 16, 2006

Web of science	WOS:000167384400010
Scopus	2-s2.0-0035090788
OpenAlex	W1964073017