Paramagnetic bioactives encapsulated in poly(D,L-lactide) microparticules: Spatial distribution and in vitro release kinetics

Paramagnetic bioactives encapsulated in poly(D,L-lactide) microparticules: Spatial distribution and in vitro release kinetics Full article

Journal

Journal of Supercritical Fluids
ISSN: 0896-8446 , E-ISSN: 1872-8162

Output data

Year: 2020, Volume: 158, Article number : 104748, Pages count : DOI: 10.1016/j.supflu.2019.104748

Tags

Release kinetics; Paramagnetic bioactives; Poly(D,L-lactide); Supercritical fluid micronization and impregnation; Electron paramagnetic resonance

Authors

Golubeva E.N. ¹ , Chumakova N.A. ¹ , Kuzin S., V ¹ , Grigoriev I.A. ³ , Kalai T. ⁴ , Korotkevich A.A. ¹ , Bogorodsky S.E. ² , Krotova L., I ² , Popov V.K. ² , Lunin V.V. ¹

Affiliations

1	(Данные Web of science) Lomonosov Moscow State Univ, Dept Chem, Leninskie Gory 1-3, Moscow 119991, Russia
2	(Данные Web of science) Russian Acad Sci, Fed Sci Res Ctr Crystallog & Photon, Inst Photon Technol, Pionerskaya 2, Moscow 108840, Russia
3	(Данные Web of science) Russian Acad Sci, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Lavrentiev Ave 9, Novosibirsk 630090, Russia
4	(Данные Web of science) Univ Pecs, Med Sch, Inst Organ & Med Chem, Szigeti St 12, H-7624 Pecs, Hungary

Poly(D,L-lactide) microparticles impregnated with a number of bioactive paramagnetic compounds have been fabricated using two SCF techniques: 1). PGSS (Particles from Gas Saturated Solution) and 2). polymer plasticization and swelling by supercritical carbon dioxide followed by its cryomilling. Electron paramagnetic resonance (EPR) spectroscopy manifested homogeneous spatial distribution for the most of these substances encapsulated into the polymer. Irreversible relaxation processes in the prepared polymer structures and formulations were not observed. The qualitative difference in the release kinetics of paramagnetic molecules of different structure from the polymer microparticles into the phosphate-buffered saline (PBS, pH = 7.4) was demonstrated, pH-sensitive ATI spin probe proved the decrease (up to <= 4.5) of local pH inside the microparticles during the first 9 days after its immersion in PBS.. ID (C) 2019 Elsevier B.V. All rights reserved.

Golubeva E.N. , Chumakova N.A. , Kuzin S.,.V. , Grigoriev I.A. , Kalai T. , Korotkevich A.A. , Bogorodsky S.E. , Krotova L.,.I. , Popov V.K. , Lunin V.V.
Paramagnetic bioactives encapsulated in poly(D,L-lactide) microparticules: Spatial distribution and in vitro release kinetics
Journal of Supercritical Fluids. 2020. V.158. 104748 . DOI: 10.1016/j.supflu.2019.104748 WOS Scopus РИНЦ

Published print:

Apr 1, 2020

Web of science	WOS:000514252800004
Scopus	2-s2.0-85077756518
Elibrary	43232298
OpenAlex	W2999806814