Effect of intramuscularly injected polyprenols on influenza virus infection in mice

Effect of intramuscularly injected polyprenols on influenza virus infection in mice Full article

Journal

Antiviral Chemistry and Chemotherapy
ISSN: 0956-3202

Output data

Year: 2000, Volume: 11, Number: 3, Pages: 239-247 Pages count : 9 DOI: 10.1177/095632020001100307

Tags

polyprenols; influenza virus; mouse model; immune reactions; animal resistance

Authors

Safatov AS ¹ , Sergeev AN ¹ , Shishkina LN ¹ , Pyankov O ¹ , Poryvaev VD ¹ , Bulychev LE ¹ , Petrishchenko VA ¹ , Pyankova OG ¹ , Zhukov VA ¹ , Ryzhikov AB ¹ , Boldyrev AN ¹ , Buryak GA ¹ , Raldugin VA ² , Kukina TP ² , Tolstikov GA ²

Affiliations

1	(Данные Web of science) SRC VB Vector RF Minist Hlth, Res Inst Aerobiol, Koltsovo 630559, Novosibirsk Reg, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

This study demonstrates the possibility of achieving a prophylactic effect by intramuscular injection of Abies sibirica polyprenols for the control of influenza virus infection in mice. One of the five polyprenol preparations tested, preparation N1. which had the lowest hydrophilic-lipophilic balance (8.6), produced a significant protective effect when injected in a dose of 2000 mu g/mouse 2 days before aerosol infection of mice with influenza virus. A moderate protective effect was also observed using a second preparation, designated N2. One day after aerosol infection, animals pre-treated with 2000 mu g doses of the polyprenol preparations or Hanks' solution showed no difference in the level of interferon accumulation in the lungs. Three days after injection of preparation N2 and N1, a significant decrease in spleen and thymus weights was observed in the mice. One day after injection of these preparations, the number of lymphocytes in the bronchoalveolar tract of the mice exceeded almost twice that seen in mice treated with placebo. After 3 days, relative and absolute numbers of macrophages decreased, whereas those of lymphocytes increased significantly. Three days after the administration of preparations N1 and N2, macrophages became approximately twice as active in absorbing zymozan granules. Preparation N1 affected the system of superoxide radical anion production to a greater extent than preparation N2. The production of radical anions by the macrophages of the bronchoalveolar tract in the mice, 1 day after intramuscular injection of preparation N1, was significantly higher than that seen on day 3 and that induced by preparation N2 1 and 3 days after injection. These data indicate that emulsions of polyprenols that have relatively low hydrophilic-lipophilic balance, inhibit influenza virus infection in mice through a modulation of the host immune response.

Safatov A. , Sergeev A. , Shishkina L. , Pyankov O. , Poryvaev V. , Bulychev L. , Petrishchenko V. , Pyankova O. , Zhukov V. , Ryzhikov A. , Boldyrev A. , Buryak G. , Raldugin V. , Kukina T. , Tolstikov G.
Effect of intramuscularly injected polyprenols on influenza virus infection in mice

Antiviral Chemistry and Chemotherapy. 2000. V.11. N3. P.239-247. DOI: 10.1177/095632020001100307 WOS Scopus РИНЦ

Full text from publisher

Published print:	Jun 1, 2000
Published online:	Jun 22, 2016

Web of science	WOS:000087988500007
Scopus	2-s2.0-0033944182
Elibrary	13357868
OpenAlex	W2014485586