Synthesis, Structure, and Cytotoxicity of Pd(II) and Cu(II) Complexes with 1-Terpenyl-3-Thiosemicarbazides of Pinane andpara-Menthane Series

Synthesis, Structure, and Cytotoxicity of Pd(II) and Cu(II) Complexes with 1-Terpenyl-3-Thiosemicarbazides of Pinane andpara-Menthane Series Full article

Journal

Journal of Structural Chemistry
ISSN: 0022-4766 , E-ISSN: 1573-8779

Output data

Year: 2020, Volume: 61, Number: 1, Pages: 44-56 Pages count : 13 DOI: 10.1134/S0022476620010059

Tags

thiosemicarbazides; terpenes; complexes; copper; palladium; structure; cytotoxicity

Authors

Kokina T.E. ^1,2 , Komarov V.Yu ^1,2 , Glinskaya L.A. ¹ , Bizyaev S.N. ³ , Sheludyakova L.A. ^1,2 , Eremina Yu A. ^1,2,4 , Klyushova L.S. ⁴ , Tkachev A., V ^2,3

Affiliations

1	(Данные Web of science) Russian Acad Sci, Nikolaev Inst Inorgan Chem, Siberian Branch, Novosibirsk, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk, Russia
3	(Данные Web of science) Russian Acad Sci, Vorozhtsov Inst Organ Chem, Siberian Branch, Novosibirsk, Russia
4	(Данные Web of science) FRC FTM, Inst Mol Biol & Biophys Subdiv, Novosibirsk, Russia

(PdLCl2)-Cl-1,2 center dot H2O (I, II) and (CuLCl2)-Cl-1 center dot H2O (III) complexes (L(1)and L(2)are 1-terpenyl-3-thiosemicarbazides of pinane andpara-menthane series, respectively) are obtained. Single crystals of complexes I and [(PdLCl2)-Cl-3] (IV) (L(3)is the product of hydrochlorination of ligand L-2) have been grown. According to XRD data, crystal structures ofI, IVconsist of complex cations [PdLCl](+)and outer-sphere anions Cl-. The coordination polyhedron N2SCl is a distorted square. L(1)and L(3)are tridentate ligands. Free ligands L-1, L(2)and complexesI-IIIare studied using IR spectroscopy; conclusions on the structure of the Cu(II) complex are inferred from the analysis of obtained data. Cytotoxic properties of L-1, complexesIandIII, as well as the carboplatin pharmaceutic are studied on the Hep2 (human larynx carcinoma) cell line. ComplexesIandIIIare shown to be moderately cytotoxic: they are twice as less toxic with respect to Hep2 cells than carboplatin that is used in the experiment as the reference complex.

Kokina T.E. , Komarov V.Y. , Glinskaya L.A. , Bizyaev S.N. , Sheludyakova L.A. , Eremina Y.A. , Klyushova L.S. , Tkachev A.,.V.
Synthesis, Structure, and Cytotoxicity of Pd(II) and Cu(II) Complexes with 1-Terpenyl-3-Thiosemicarbazides of Pinane andpara-Menthane Series
Journal of Structural Chemistry. 2020. V.61. N1. P.44-56. DOI: 10.1134/S0022476620010059 WOS Scopus РИНЦ

Кокина Т.Е. , Комаров В.Ю. , Глинская Л.А. , Бизяев С.Н. , Шелудякова Л.А. , Еремина Ю.А. , Клюшова Л.С. , Ткачев А.В.
Синтез, строение и цитотоксичность комплексов Pd(II) и Cu(II) с 1-терпенил-3-тиосемикарбазидами пинанового и п-ментанового рядов
Журнал структурной химии (J STRUCT CHEM+). 2020. Т.61. №1. С.48-61. DOI: 10.26902/JSC_id49663 РИНЦ

Published print:	Jan 1, 2020
Published online:	Jul 14, 2020

Web of science	WOS:000548452300005
Scopus	2-s2.0-85087933177
Elibrary	45454702
OpenAlex	W3043196868