CHANGES IN THE BLOOD FATTY-ACID PROFILE ASSOCIATED WITH OXIDATIVE-ANTIOXIDANT DISTURBANCES IN CORONARY ATHEROSCLEROSIS

CHANGES IN THE BLOOD FATTY-ACID PROFILE ASSOCIATED WITH OXIDATIVE-ANTIOXIDANT DISTURBANCES IN CORONARY ATHEROSCLEROSIS Full article

Journal

Journal of Medical Biochemistry
ISSN: 1452-8258 , E-ISSN: 1452-8266

Output data

Year: 2020, Volume: 39, Number: 1, Pages: 46-53 Pages count : 8 DOI: 10.2478/jomb-2019-0010

Tags

atherosclerosis; atherosclerotic plaque; fatty acid; lipid; lipoprotein-associated phospholipase 2; oxidative stress

Authors

Ragino Yuliya, I ¹ , Shramko Viktoriva S. ¹ , Stakhneva Ekaterina M. ¹ , Chernyak Elena, I ² , Morozov Sergey, V ² , Shakhtshneider Elena, V ^1,4 , Polonskaya Yana, V ¹ , Shcherbakova Liliia, V ¹ , Chernvayskiy Alexander M. ³

Affiliations

1	(Данные Web of science) Russian Acad Sci IIPM Branch IC&G SB RAS, Inst Internal & Prevent Med, Branch Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Sci NIOCH SB RAS, Siberian Branch, NN Vorozhtsov Inst Organ Chem, Novosibirsk, Russia
3	(Данные Web of science) Minist Hlth Russian Federat, Fed Publicly Funded Inst, Meshalkin Natl Med Res Ctr, Novosibirsk, Russia
4	(Данные Web of science) Novosibirsk State Univ, Novosibirsk, Russia

Background: The objective of this work was to study the profile of fatty acids and to search for associations of fatty acids with oxidative-antioxidant parameters and an oxidative-inflammatory biomarker (lipoprotein-associated phospholipase A2) in men with coronary atherosclerosis and coronary heart disease. Methods: Analysis of 20 fatty acids was performed in 60 men with angiographically confirmed coronary atherosclerosis and coronary heart disease and in a control group of men without coronary heart disease. Serum fatty-acid content was evaluated by high-performance gas-liquid chromatography. The blood levels of oxidative stress, total antioxidative defence, and lipoprotein-associated phospholipase 2 were analyzed. Results: In the group of men with coronary atherosclerosis the levels of myristic and palmitic fatty acids were higher by 59% and 22%, respectively. An increase in the weight percentage of monounsaturated fatty acids was noted, such as palmitoleic, oleic, and octadecenic. Significantly lower levels of polyunsaturated fatty acids, such as linolic, eicosadienoic, eicosatrienoic, arachidonic, eicosapentaenoic, gamma-linolenic, docosapentaenoic, and docosahexaenoic were detected in the group with coronary atherosclerosis. The lipoprotein-associated phospholipase A2 level was higher by 48%. Oxidative stress was higher by 17%, and the total antioxidant defence in serum was lower by 45%. We found correlations between fatty acids and oxidative-antioxidative alterations. The relative risk of vulnerable atherosclerotic plaques correlated with increased levels of palmitic, stearic, oleic, and linolic fatty acids. Conclusions: Significant alterations in the profile of fatty acids are associated with oxidative-antioxidative alterations and are accompanied by an increase in free-radical formation, which can probably serve as a risk factor of atherosclerosis.

Ragino Y.I. , Shramko V.S. , Stakhneva E.M. , Chernyak E.I. , Morozov S.V. , Shakhtshneider E.V. , Polonskaya Y.V. , Shcherbakova L.V. , Chernvayskiy A.M.
CHANGES IN THE BLOOD FATTY-ACID PROFILE ASSOCIATED WITH OXIDATIVE-ANTIOXIDANT DISTURBANCES IN CORONARY ATHEROSCLEROSIS

Journal of Medical Biochemistry. 2020. V.39. N1. P.46-53. DOI: 10.2478/jomb-2019-0010 WOS Scopus РИНЦ

Full text from publisher

Published print:

Mar 26, 2019

Web of science	WOS:000543791400008
Scopus	2-s2.0-85063732237
Elibrary	38722571
OpenAlex	W2933313745