SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF TYROSOL AND ITS STRUCTURAL ANALOGS

SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF TYROSOL AND ITS STRUCTURAL ANALOGS Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031

Output data

Year: 2019, Volume: 52, Number: 11, Pages: 907-911 Pages count : DOI: 10.1007/s11094-019-01924-1

Tags

p-tyrosol; hydroxyalkylphenols; anti-inflammatory and antiulcer activity

Authors

Krysin A. P. ¹ , Tolstikova T. G. ¹ , Dolgikh M. P. ¹ , Shul'ts E. E. ¹ , Pokrovskii L. M. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, 9 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia

The anti-inflammatory activity of tyrosol and 12 structural analogs including 3 new compounds was determined. Several structure-activity (anti-inflammatory) relationships were found. Adding a tert-butyl substituent to the aromatic ring and increasing the length of the alkyl chain decreased the anti-inflammatory activity. Pronounced antiulcer activity was found for p-tyrosol.

Krysin A.P. , Tolstikova T.G. , Dolgikh M.P. , Shul'ts E.E. , Pokrovskii L.M.
SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF TYROSOL AND ITS STRUCTURAL ANALOGS
Pharmaceutical Chemistry Journal. 2019. V.52. N11. P.907-911. DOI: 10.1007/s11094-019-01924-1 WOS Scopus РИНЦ

Крысин А.П. , Толстикова Т.Г. , Долгих М.П. , Шульц Э.Э. , Покровский Л.М.
Синтез и противовоспалительная активность тирозола и его структурных аналогов

Химико-фармацевтический журнал (PHARM CHEM J+). 2018. Т.52. №11. С.32-36. DOI: 10.30906/0023-1134-2018-52-11-32-36 РИНЦ

Published print:	Feb 1, 2019
Published online:	Feb 12, 2019

Web of science	WOS:000461018000005
Scopus	2-s2.0-85061494185
Elibrary	38666851
OpenAlex	W2914511859