Synthesis and Antiviral Activity of Polycyclic N-Amidoimides Based on 4-Oxatetracyclo-[5.3.2.0(2,6).0(8,10)]Dodec-11-Ene-3,5-Dione

Synthesis and Antiviral Activity of Polycyclic N-Amidoimides Based on 4-Oxatetracyclo-[5.3.2.0(2,6).0(8,10)]Dodec-11-Ene-3,5-Dione Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031

Output data

Year: 2019, Volume: 52, Number: 10, Pages: 820-824 Pages count : 5 DOI: 10.1007/s11094-019-1907-9

Tags

polycyclic amidoimides; hydrazides; benzoic acids; arylaminoacetic acid; Vaccinia virus; antiviral activity; pharmacological activity

Authors

Selivanov B.A. ¹ , Bormotov N.I. ² , Shishkina L.N. ² , Belanov E.F. ² , Serova O.A. ² , Kabanov A.S. ² , Mazurkov O.Yu. ² , Tikhonov A.Ya. ¹

Affiliations

1	(Данные Web of science) RAS, SB, Russian Acad Sci NIOCh, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Akad Lavrenteva, Novosibirsk 630090 90, Russia
2	(Данные Web of science) Vector State Res Ctr Virol & Biotechnol, Koltsov 630559, Novosibirsk Obl, Russia

A series of novel polycyclic N-amidoimides were synthesized by reacting 4-oxatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-ene-3,5-dione with hydrazides of benzoic acids, arylaminoacetic acid, and oxalic acid. The most pronounced antiviral activities against Vaccinia virus were observed for 4-hydroxy-N-(3,5-dioxo-4-azatetracyclo[5.3.2.0(2, 6).0(8, 10)]dodec-11-en-4-yl)-3-nitrobenzamide, N-(3,5-dioxo-4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-en-4-yl)-N-[(3-trifluoromethyl)phenyl]ethanediamide, and N-(2,6-dimethylphenyl)-N-(3,5-dioxo-4-azatetracyclo-5.3.2.0(2,6),0(8,10)]dodec-11-en-4-yl)ethanediamide.

Selivanov B.A. , Bormotov N.I. , Shishkina L.N. , Belanov E.F. , Serova O.A. , Kabanov A.S. , Mazurkov O.Y. , Tikhonov A.Y.
Synthesis and Antiviral Activity of Polycyclic N-Amidoimides Based on 4-Oxatetracyclo-[5.3.2.0(2,6).0(8,10)]Dodec-11-Ene-3,5-Dione
Pharmaceutical Chemistry Journal. 2019. V.52. N10. P.820-824. DOI: 10.1007/s11094-019-1907-9 WOS Scopus РИНЦ

Селиванов Б.А. , Бормотов Н.И. , Скурат Л.Н. , Беланов Е.Ф. , Серова О.А. , Кабанов А.С. , Мазурков О.Ю. , Тихонов А.Я.
СИНТЕЗ И ПРОТИВОВИРУСНАЯ АКТИВНОСТЬ ПОЛИЦИКЛИЧЕСКИХ N-АМИДОИМИДОВ НА ОСНОВЕ 4-ОКСАТЕТРАЦИКЛО-[5.3.2.02,6.08,10]ДОДЕЦ-11-ЕН-3,5-ДИОНА

Химико-фармацевтический журнал (PHARM CHEM J+). 2018. Т.52. №10. С.3-7. DOI: 10.30906/0023-1134-2018-52-10-3-7 РИНЦ

Published print:	Jan 1, 2019
Published online:	Jan 7, 2019

Web of science	WOS:000455979900002
Scopus	2-s2.0-85059677766
Elibrary	38642868
OpenAlex	W2908718144