Polyunsaturated Fatty Acids and Their Correlations with Parameters of Oxidative/Antioxidant Potential of the Blood and Lipoprotein-Associated Phospholipase A2 in Coronary Atherosclerosis

Polyunsaturated Fatty Acids and Their Correlations with Parameters of Oxidative/Antioxidant Potential of the Blood and Lipoprotein-Associated Phospholipase A2 in Coronary Atherosclerosis Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2018, Volume: 166, Number: 1, Pages: 11-14 Pages count : DOI: 10.1007/s10517-018-4277-5

Tags

coronary atherosclerosis; fatty acids; oxidative stress; antioxidant defense; lipoprotein-associated phospholipase A2

Authors

Shramko V. S. ¹ , Polonskaya Ya. V. ¹ , Morozov S. V. ² , Chernyak E. I. ² , Chernyavsky A. M. ³ , Ragino Yu. I. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Res Inst Internal & Prevent Med, Fed Res Ctr Inst Cytol & Genet, Affiliated Branch,Siberian Div, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Inst Organ Chem, Siberian Div, Novosibirsk, Russia
3	(Данные Web of science) Minist Hlth Russian Federat, EN Meshalkin Natl Med Res Ctr, Novosibirsk, Russia

We studied serum content of some polyunsaturated fatty acids and their correlations with parameters of oxidative stress (FORT), antioxidant protection (FORD), lipoprotein-associated phospholipase A2 (LP-PLA2), and serum level of LPO products in male patients with coronary atherosclerosis. The mass fraction of polyunsaturated fatty acids and FORD were lower, while LP-PLA2, FORT, and concentration of LPO products were higher than in the control group (conventionally healthy men). Negative correlations of medium strength of polyunsaturated fatty acids with inflammation markers and oxidative stress were revealed, which can indicate that the decrease in polyunsaturated fatty acids content is associated with enhanced generation of free radicals, and consequently with increased risk of early atherosclerosis development.

Shramko V.S. , Polonskaya Y.V. , Morozov S.V. , Chernyak E.I. , Chernyavsky A.M. , Ragino Y.I.
Polyunsaturated Fatty Acids and Their Correlations with Parameters of Oxidative/Antioxidant Potential of the Blood and Lipoprotein-Associated Phospholipase A2 in Coronary Atherosclerosis
Bulletin of Experimental Biology and Medicine. 2018. V.166. N1. P.11-14. DOI: 10.1007/s10517-018-4277-5 WOS Scopus РИНЦ

Шрамко В.С. , Полонская Я.В. , Морозов С.В. , Черняк Е.И. , Чернявский А.М. , Рагино Ю.И.
Полиненасыщенные жирные кислоты и их ассоциации с параметрами окислительно-антиоксидантного потенциала крови и липопротеинассоциированной фосфолипазой a2 при коронарном атеросклерозе
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2018. Т.166. №7. С.14-17. РИНЦ

Published print:	Nov 1, 2018
Published online:	Nov 12, 2018

Web of science	WOS:000452549900003
Scopus	2-s2.0-85056384718
Elibrary	38623956
OpenAlex	W2901187578