Atorvastatin calcium inclusion complexation with polysaccharide arabinogalactan and saponin disodium glycyrrhizate for increasing of solubility and bioavailability

Atorvastatin calcium inclusion complexation with polysaccharide arabinogalactan and saponin disodium glycyrrhizate for increasing of solubility and bioavailability Full article

Journal

Drug Delivery and Translational Research
ISSN: 2190-393X , E-ISSN: 2190-3948

Output data

Year: 2018, Volume: 8, Number: 5, Pages: 1200-1213 Pages count : 14 DOI: 10.1007/s13346-018-0565-x

Tags

Atorvastatin calcium; Mechanochemistry; Solubility; Supramolecular complexes; Arabinogalactan; Disodium glycyrrhizin

Authors

Kong Ruiping ¹ , Zhu Xingyi ¹ , Meteleva Elizaveta S. ² , Polyakov Nikolay E. ³ , Khvostov Mikhail V. ^4,5 , Baev Dmitry S. ^4,5 , Tolstikova Tatjana G. ^4,5 , Dushkin Alexander V. ^1,2 , Su Weike ¹

Affiliations

1	(Данные Web of science) Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China
2	(Данные Web of science) RAS, SB, Inst Solid State Chem & Mechanochem, Novosibirsk 630128, Russia
3	(Данные Web of science) RAS, SB, Inst Chem Kinet & Combust, Novosibirsk, Russia
4	(Данные Web of science) RAS, SB, NN Vorozhtsov Inst Organ Chem, Novosibirsk, Russia
5	(Данные Web of science) Novosibirsk State Univ, Novosibirsk, Russia

The aim of the present investigation was to enhance the solubility and dissolution of atorvastatin calcium (ATV), a poorly water-soluble drug with larch polysaccharide arabinogalactan (AG) and disodium glycyrrhizate (Na(2)GA) as carriers of drug delivery systems for improving its bioavailability. The interactions of ATV with AG or Na(2)GA were investigated by DSC. XRD, SEM, and NMR techniques. The molecular weights of supramolecular systems-inclusion complexes and micelles-which are the hosts for ATV molecules were measured. On the other hand, the rapid storage assay (+ 40 degrees C for 3 months) showed that the chemical stability of ATV/AG and ATV/Na(2)GA complexes had been enhanced compared with pure ATV. In vitro drug release showed a significant increase in ATV's dissolution rate after formation of a complex with Na(2)GA or AG. Pharmacokinetic tests in vivo on laboratory animals showed a significant increase in ATV's bioavailability after its introduction as a complex with Na(2)GA or AG. Moreover. ATV/AG and ATV/Na(2)GA complexes showed a more prominent decrease of total cholesterol (TC) level compared to net ATV. Therefore, the novel mechanochemically synthesized complexes of ATV with AG or Na(2)GA as drug delivery systems might be potential and promising candidates for hypercholesterolemia treatment and deserved further researches.

Kong R. , Zhu X. , Meteleva E.S. , Polyakov N.E. , Khvostov M.V. , Baev D.S. , Tolstikova T.G. , Dushkin A.V. , Su W.
Atorvastatin calcium inclusion complexation with polysaccharide arabinogalactan and saponin disodium glycyrrhizate for increasing of solubility and bioavailability
Drug Delivery and Translational Research. 2018. V.8. N5. P.1200-1213. DOI: 10.1007/s13346-018-0565-x WOS Scopus РИНЦ

Published online:	Jul 23, 2018
Published print:	Oct 1, 2018

Web of science	WOS:000442867500021
Scopus	2-s2.0-85052281627
Elibrary	35769822
OpenAlex	W2884975589