Synthesis and structures of Cu-I,Cu-II complexes with a 2,2 '-bipyridine derivative bearing a (+)-3-carene moiety

Synthesis and structures of Cu-I,Cu-II complexes with a 2,2 '-bipyridine derivative bearing a (+)-3-carene moiety Full article

Journal

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Output data

Year: 2018, Volume: 67, Number: 7, Pages: 1251-1260 Pages count : DOI: 10.1007/s11172-018-2209-1

Tags

copper(I, II) complexes; chiral ligand; terpenes; iodide complex; crystal structure; coordination framework; cytotoxicity

Authors

Kokina T. E. ^1,2 , Glinskaya L. A. ¹ , Piryazev D. A. ¹ , Baranov A. Yu. ^2,3 , Agafontsev A. M. ^2,3 , Eremina Yu. A. ^1,2 , Vorontsova E. V. ⁴ , Bogomyakov A. S. ⁵ , Naumov D. Yu. ^1,2 , Tkachev A. V. ^2,3 , Larionov S. V. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Nikolaev Inst Inorgan Chem, 3 Prosp Akad Lavrentieva, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, 2 Ul Pirogova, Novosibirsk 630090, Russia
3	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Akad Lavrentieva, Novosibirsk 630090, Russia
4	(Данные Web of science) Inst Mol Biol & Biophys, 2-12 Ul Timakova, Novosibirsk 630117, Russia
5	(Данные Web of science) Russian Acad Sci, Siberian Branch, Int Tomog Ctr, 3a Ul Inst Skaya, Novosibirsk 630090, Russia

The complex salt {[CuL2][Cu4I6]center dot MeCN}(n) (1) and the compound [Cu4L3I4]center dot 3 MeCN (2) (L is a chiral ligand bearing a natural monoterpene (+)-3-carene moiety) were synthesized. The crystal structures of compounds 1 and 2 were determined by X-ray diffraction. The structure of compound 1 consists of complex cations [CuL2](2+) (N3O2 polyhedron is a trigonal bipyramid) and Cu-I coordination polymers (CuI4 polyhedron is a tetrahedron) as anions. The experimental magnetic moment mu(eff) at 300 K is 1.90 mu(B), which is consistent with the X-ray diffraction data and the assumption that compound 1 is mixed-valence. The structure of compound 2 comprises a tetranuclear Cu-I complex, in which three Cu atoms are coordinated by two N atoms of the ligand L and two I atoms, and the fourth Cu atom is coordinated by four I atoms (coordination polyhedra are distorted tetrahedra). Compounds L and 2 were found to influence the viability of human laryngeal carcinoma cells (Hep2). The IC50 value for complex 2 (13.0 +/- 1.7 mu M) is substantially smaller than IC50 for compound L (30.5 +/- 0.5 mu M).

Kokina T.E. , Glinskaya L.A. , Piryazev D.A. , Baranov A.Y. , Agafontsev A.M. , Eremina Y.A. , Vorontsova E.V. , Bogomyakov A.S. , Naumov D.Y. , Tkachev A.V. , Larionov S.V.
Synthesis and structures of Cu-I,Cu-II complexes with a 2,2 '-bipyridine derivative bearing a (+)-3-carene moiety
Russian Chemical Bulletin. 2018. V.67. N7. P.1251-1260. DOI: 10.1007/s11172-018-2209-1 WOS Scopus РИНЦ

Кокина Т.Е. , Глинская Л.А. , Пирязев Д.А. , Баранов А.Ю. , Агафонцев А.М. , Еремина Ю.А. , Воронцова Е.В. , Богомяков А.С. , Наумов Д.Ю. , Ткачев А.В. , Ларионов С.В.
Синтез и строение комплексов cuii,i и cui с производным 2,2’-бипиридина, содержащим фрагмент природного монотерпена (+)-3-карена
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2018. №7. С.1251-1260. РИНЦ

Published print:	Jul 1, 2018
Published online:	Oct 2, 2018

Web of science	WOS:000446191100017
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