Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt

Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt Full article

Journal

Doklady Biochemistry and Biophysics
ISSN: 1607-6729 , E-ISSN: 1608-3091

Output data

Year: 2018, Volume: 481, Number: 1, Pages: 228-231 Pages count : DOI: 10.1134/S1607672918040142

Authors

Meteleva E. S. ¹ , Chistyachenko Yu. S. ¹ , Suntsova L. P. ¹ , Tsyganov M. A. ² , Vishnivetskaya G. B. ² , Avgustinovich D. F. ² , Khvostov M. V. ^3,5 , Polyakov N. E. ⁴ , Tolstikova T. G. ^3,5 , Mordvinov V. A. ² , Dushkin A. V. ¹ , Lyakhov N. Z. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Solid State Chem & Mechanochem, Novosibirsk 630128, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Novosibirsk 630090, Russia
3	(Данные Web of science) Russian Acad Sci, Vorozhtsov Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
4	(Данные Web of science) Russian Acad Sci, Voevodsky Inst Chem Kinet & Combust, Siberian Branch, Novosibirsk 630090, Russia
5	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

The mechanochemical preparation of solid compositions of praziquantel with plant saponin (glycyrrhizic acid disodium salt) is described. The study of a number of physicochemical parameters showed that dissolving solid compositions in water is accompanied by the inclusion of praziquantel molecules into micelles, which are formed in the solution of the glycyrrhizic acid disodium salt. Using the opisthorchiasis model caused by Opisthorchis felineus, we found a 4- to 11-fold increase in the anthelmintic activity of praziquantel in the composition as compared to the official praziquantel. According to the pharmacokinetic data, the use of the composition increased the bioavailability of praziquantel 3 times.

Meteleva E.S. , Chistyachenko Y.S. , Suntsova L.P. , Tsyganov M.A. , Vishnivetskaya G.B. , Avgustinovich D.F. , Khvostov M.V. , Polyakov N.E. , Tolstikova T.G. , Mordvinov V.A. , Dushkin A.V. , Lyakhov N.Z.
Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt
Doklady Biochemistry and Biophysics. 2018. V.481. N1. P.228-231. DOI: 10.1134/S1607672918040142 WOS Scopus РИНЦ

Метелева Е.С. , Чистяченко Ю.С. , Сунцова Л.П. , Цыганов М.А. , Вишнивецкая Г.Б. , Августинович Д.Ф. , Хвостов М.В. , Поляков Н.Э. , Толстикова Т.Г. , Мордвинов В.А. , Душкин А.В. , Ляхов Н.З.
Физико-химические свойства и противоописторхозное действие механохимически синтезированных твердых композиций празиквантела и динатриевой соли глицирризиновой кислоты
Доклады академии наук. 2018. Т.481. №6. С.694-697. DOI: 10.31857/S086956520002111-5 РИНЦ

Published print:	Jul 1, 2018
Published online:	Aug 31, 2018

Web of science	WOS:000443322200014
Scopus	2-s2.0-85052732665
Elibrary	35761345
OpenAlex	W2888965909