New Ionic Conjugates Based on alpha-Tocopheryl Succinate as Potential Cytotoxic Agents

New Ionic Conjugates Based on alpha-Tocopheryl Succinate as Potential Cytotoxic Agents Full article

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Output data

Year: 2018, Volume: 44, Number: 3, Pages: 330-336 Pages count : 7 DOI: 10.1134/S1068162018030068

Tags

alpha-tocopheryl succinate; mitocans; nitroxide radicals; spin-labeled derivatives; cytotoxicity; antioxidants; ionic conjugates

Authors

Frolova T.S. ^1,2,3 , Sharapov S.Z. ^2,3 , Sinitsyna O.I. ^2,3 , Tolstikova T.G. ^1,3 , Grigoriev I.A. ⁴ , Morozov S.V. ^1,3 , Yushkova Y.V. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
3	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
4	(Данные Web of science) Meshalkin State Res Inst Circulat Pathol, Novosibirsk, Russia

Five new ionic conjugates based on alpha-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments.

Frolova T.S. , Sharapov S.Z. , Sinitsyna O.I. , Tolstikova T.G. , Grigoriev I.A. , Morozov S.V. , Yushkova Y.V.
New Ionic Conjugates Based on alpha-Tocopheryl Succinate as Potential Cytotoxic Agents
Russian Journal of Bioorganic Chemistry. 2018. V.44. N3. P.330-336. DOI: 10.1134/S1068162018030068 WOS Scopus РИНЦ

Фролова Т.С. , Шарапов С.Ж. , Синицына О.И. , Толстикова Т.Г. , Григорьев И.А. , Морозов С.В. , Юшкова Ю.В.
НОВЫЕ ИОННЫЕ КОНЪЮГАТЫ НА ОСНОВЕ A-ТОКОФЕРИЛСУКЦИНАТА КАК ПОТЕНЦИАЛЬНЫЕ ЦИТОТОКСИЧЕСКИЕ АГЕНТЫ1)
Биоорганическая химия (RUSS J BIOORG CHEM+). 2018. Т.44. №3. С.325-332. DOI: 10.7868/S0132342318030089 РИНЦ

Published print:	May 1, 2018
Published online:	Jun 13, 2018

Web of science	WOS:000435369100008
Scopus	2-s2.0-85048556773
Elibrary	35720066
OpenAlex	W2807824397