Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan

Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan Full article

Journal

Chemical Papers
ISSN: 0366-6352 , E-ISSN: 1336-9075

Output data

Year: 2018, Volume: 72, Number: 5, Pages: 1257-1263 Pages count : 7 DOI: 10.1007/s11696-017-0362-x

Tags

Betulin diacetate; Arabinogalactan; Complexes; Microwave synthesis; Films; Antitumor activity

Authors

Malyar Yuriy N. ^1,5 , Mikhailenko Mikhail A. ² , Pankrushina Natalia A. ³ , Mikheev Alexander N. ⁴ , Eltsov Ilia V. ⁴ , Kuznetsova Svetlana A. ^1,5 , Kichkailo Anna S. ⁶ , Shakhtshneider Tatyana P. ^2,4

Affiliations

1	(Данные Web of science) Krasnoyarsk Sci Ctr SB RAS, Fed Res Ctr, Inst Chem & Chem Technol SB RAS, Akademgorodok 50-24, Krasnoyarsk 5024, Russia
2	(Данные Web of science) Inst Solid State Chem & Mechanochem SB RAS, Kutateladze Str 18, Novosibirsk 630128, Russia
3	(Данные Web of science) Novosibirsk Inst Organ Chem SB RAS, Lavrentyev Ave 9, Novosibirsk 630090, Russia
4	(Данные Web of science) Novosibirsk State Univ, Pirogova Str 2, Novosibirsk 630090, Russia
5	(Данные Web of science) Siberian Fed Univ, Svobodny Ave 79, Krasnoyarsk 660041, Russia
6	(Данные Web of science) Krasnoyarsk State Med Univ, Partizana Zheleznyaka Str 1, Krasnoyarsk 660022, Russia

In this work, a water-soluble supramolecular complex was synthesized in an aqueous suspension of betulin diacetate (BDA) and arabinogalactan (AG) upon microwave heating. Microwave heating allows reducing the time required for the complex formation, compared with conventional heating in a water bath. The specific effect of microwave irradiation on the initial reagents and preparation of a supramolecular complex was studied. In contrast to conventional heating, under microwave heating AG macromolecules may break into roughly equal fragments when the temperature increases up to 100 A degrees C. A change in the surface morphology of BDA crystals under microwave heating of the suspension suggests that microwave irradiation facilitates the dissolution of BDA in water. It has been shown that the use of dimethylsulfoxide as a reaction medium for microwave heating led to a decrease in BDA content in the product due to the inclusion of DMSO into AG macromolecules. The BDA-AG complex was isolated from the microwave-heated aqueous solution, after water evaporation, as a thin amorphous film, which exhibited antitumor activity against Ehrlich ascites carcinoma cells and can be a promising material for pharmacological applications.

Malyar Y.N. , Mikhailenko M.A. , Pankrushina N.A. , Mikheev A.N. , Eltsov I.V. , Kuznetsova S.A. , Kichkailo A.S. , Shakhtshneider T.P.
Microwave-assisted synthesis and antitumor activity of the supramolecular complexes of betulin diacetate with arabinogalactan

Chemical Papers. 2018. V.72. N5. P.1257-1263. DOI: 10.1007/s11696-017-0362-x WOS Scopus РИНЦ

Full text from publisher

Published online:	Dec 11, 2017
Published print:	May 1, 2018

Web of science	WOS:000430502800020
Scopus	2-s2.0-85060347961
Elibrary	38705897
OpenAlex	W2774615105