Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma

Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031

Output data

Year: 2018, Volume: 51, Number: 12, Pages: 1102-1105 Pages count : DOI: 10.1007/s11094-018-1748-y

Tags

camphecin; plasma; validation; GC-MS

Authors

Sokolova A. S. ^1,2 , Yarovaya O. I. ^1,2 , Nefedov A. A. ^1,2 , Salakhutdinov N. F. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Pr Akad Lavrenteva, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, 2 Pirogova St, Novosibirsk 630090, Russia

A new GC-MS method for determining an antiviral agent (camphecin) in blood plasma was developed. Sample preparation consisted of precipitating proteins using MeOH. The method was validated for selectivity, calibration curve, accuracy, precision, limit of quantitation, carryover, and stability. The analytical range was 0.1 - 2 mu g/mL. The method could be used for pharmacokinetic studies.

Sokolova A.S. , Yarovaya O.I. , Nefedov A.A. , Salakhutdinov N.F.
Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma
Pharmaceutical Chemistry Journal. 2018. V.51. N12. P.1102-1105. DOI: 10.1007/s11094-018-1748-y WOS Scopus РИНЦ

Соколова А.С. , Яровая О.И. , Нефедов А.А. , Салахутдинов Н.Ф.
Разработка и валидация методики определения нового эффективного ингибитора вируса гриппа h1n1 в плазме крови
Химико-фармацевтический журнал (PHARM CHEM J+). 2017. Т.51. №12. С.30-33. РИНЦ

Published print:	Mar 1, 2018
Published online:	Mar 12, 2018

Web of science	WOS:000430477400011
Scopus	2-s2.0-85043467305
Elibrary	35511668
OpenAlex	W2793297440