Nitro derivatives of 2,1,3-benzothiadiazole 1-oxides: synthesis, structural study, and NO release

Nitro derivatives of 2,1,3-benzothiadiazole 1-oxides: synthesis, structural study, and NO release Full article

Journal

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Output data

Year: 2018, Volume: 67, Number: 1, Pages: 95-101 Pages count : DOI: 10.1007/s11172-018-2042-6

Tags

1,2,5-thiadiazole 1-oxides; sulfur monochloride; ortho-nitroamino derivatives; synthesis; nitric oxide

Authors

Konstantinova L. S. ¹ , Knyazeva E. A. ¹ , Gatilov Yu. V. ² , Zlotin S. G. ¹ , Rakitin O. A. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia

A convenient one-pot synthesis of nitro derivatives of 2,1,3-benzothiadiazole 1-oxides by the reaction of o-nitroanilines with sulfur monochloride was developed. The structural features of 4-nitrobenzothiadiazole and its N-oxide were considered. High in vitro release of nitric oxide (69%) was found for a 6-nitro-2,1,3-benzothiadiazole sample by the Griess assay, which indicated good prospects for this class of compounds.

Konstantinova L.S. , Knyazeva E.A. , Gatilov Y.V. , Zlotin S.G. , Rakitin O.A.
Nitro derivatives of 2,1,3-benzothiadiazole 1-oxides: synthesis, structural study, and NO release
Russian Chemical Bulletin. 2018. V.67. N1. P.95-101. DOI: 10.1007/s11172-018-2042-6 WOS Scopus РИНЦ

Константинова Л.С. , Князева Е.А. , Гатилов Ю.В. , Злотин С.Г. , Ракитин О.А.
Синтез и исследование структуры нитропроизводных 1-оксидов 2,1,3-бензотиадиазолов и их способности выделять no
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2018. №1. С.95-101. РИНЦ

Published print:	Jan 1, 2018
Published online:	Apr 19, 2018

Web of science	WOS:000430480200013
Scopus	2-s2.0-85045841618
Elibrary	35491511
OpenAlex	W2799463913