Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates

Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates Full article

Journal

Saudi Pharmaceutical Journal
ISSN: 1319-0164 , E-ISSN: 2213-7475

Output data

Year: 2018, Volume: 26, Number: 1, Pages: 84-92 Pages count : 9 DOI: 10.1016/j.jsps.2017.10.008

Tags

Trolox; Amines; Ion conjugates; Antioxidants; Mass-spectrometry

Authors

Yushkova Yuliya V. ¹ , Chernyak Elena I. ¹ , Gatilov Yuriy V. ^1,2 , Vasil'ev Vladimir G. ¹ , Morozov Sergey V. ^1,2 , Grigor'ev Igor A. ^1,3

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, NIOCH, 9 Acad Lavrent,Ev Ave, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ NSU, 2 Pirogova Str, Novosibirsk 630090, Russia
3	(Данные Web of science) Academician EN Meshalkin State Res Inst Circulat, 15 Rechkunovskaya Str, Novosibirsk 630055, Russia

The interaction of trolox with ammonia, alkylamines of different classes, and amino derivatives of heterocyclic compounds, including nitroxyl radicals and alkaloids, led to the production of ammonium salts called ion conjugates (ICs). Five ICs were characterised by X-ray diffraction. This is the first time a wide range of ICs were made from trolox with amines, and ESI-MS data demonstrated they have the potential to generate pseudomolecular [(A(-)B(+)) + H](+) ions. For all obtained trolox ICs, a significant increase (1-3 orders of magnitude) in water solubility was achieved while retaining high antioxidant activity. ICs synthesised from two biologically active fragments may be used to create polyfunctional agents with varying solubility and bioavailability. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

Yushkova Y.V. , Chernyak E.I. , Gatilov Y.V. , Vasil'ev V.G. , Morozov S.V. , Grigor'ev I.A.
Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates

Saudi Pharmaceutical Journal. 2018. V.26. N1. P.84-92. DOI: 10.1016/j.jsps.2017.10.008 WOS Scopus

Full text from publisher

Published print:

Jan 1, 2018

Web of science	WOS:000423066700013
Scopus	2-s2.0-85045291577
OpenAlex	W2761038410