Synthesis and Analgesic Activity of 5,7-and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties

Synthesis and Analgesic Activity of 5,7-and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2017, Volume: 53, Number: 6, Pages: 1131-1136 Pages count : 6 DOI: 10.1007/s10600-017-2216-8

Tags

diazaadamantanes; monoterpenes; tertiary amines; hot plate; acetate writhing; pain

Authors

Ponomarev K.Yu. ¹ , Morozova E.A. ¹ , Suslov E.V. ¹ , Korchagina D.V. ¹ , Tolstikova T.G. ^1,2 , Volcho K.P. ^1,2 , Salakhutdinov N.F. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, 9 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk Natl Res State Univ, 2 Pirogova St, Novosibirsk 630090, Russia

A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.

Ponomarev K.Y. , Morozova E.A. , Suslov E.V. , Korchagina D.V. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
Synthesis and Analgesic Activity of 5,7-and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties
Chemistry of Natural Compounds. 2017. V.53. N6. P.1131-1136. DOI: 10.1007/s10600-017-2216-8 WOS Scopus РИНЦ

Published print:	Nov 1, 2017
Published online:	Nov 22, 2017

Web of science	WOS:000416801100026
Scopus	2-s2.0-85034634696
Elibrary	41776467
OpenAlex	W2769824158