Complexes of Cu(I) and Pd(II) with (+)-Camphor and (-)-Cavrone Thiosemicarbazones: Synthesis, Structure, and Cytotoxicity of the Pd(II) Complex

Complexes of Cu(I) and Pd(II) with (+)-Camphor and (-)-Cavrone Thiosemicarbazones: Synthesis, Structure, and Cytotoxicity of the Pd(II) Complex Full article

Journal

Russian Journal of General Chemistry
ISSN: 1070-3632 , E-ISSN: 1608-3350

Output data

Year: 2017, Volume: 87, Number: 10, Pages: 2332-2342 Pages count : DOI: 10.1134/S1070363217100140

Tags

thiosemicarbazone; terpene; Cu(I) complex; Pd(II) complex; cytotoxicity

Authors

Kokina T. E. ^1,2 , Sheludyakova L. A. ^1,2 , Eremina Yu. A. ^1,2 , Vorontsova E. V. ³ , Glinskaya L. A. ¹ , Piryazev D. A. ^1,2 , Lider E. V. ^1,2 , Tkachev A. V. ^2,4 , Larionov S. V. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Nikolaev Inst Inorgan Chem, Siberian Branch, Pr Akad Lavrenteva 3, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk, Russia
3	(Данные Web of science) Russian Acad Med Sci, Res Inst Mol Biol & Biophys, Siberian Branch, Novosibirsk, Russia
4	(Данные Web of science) Russian Acad Sci, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk, Russia

CuLCl, (CuLCl)-Cl-1, PdLCl2, and (PdLCl2)-Cl-1 complexes [L and L-1 being (+)-camphor and (-)-carvone thiosemicarbazones, respectively] have been synthesized. The structure of binuclear [Pd2L2 Cl-2(4)] complex has been determined by means of X-ray diffraction. The L-2 ligand (dehydrogenated (-)-carvone thiosemicarbazone) is coordinated via the bridging S atom to two Pd atoms. The complexes of Cu(I) and Pd(II) presumably have polynuclear and binuclear structure, respectively. These facts are in good agreement with IR and NMR spectroscopy as well as mass spectrometry data which indicate the coordination of L and L-1 ligands via the S atom. The influence of L-1 and (PdLCl2)-Cl-1 on viability of the Hep2 cell line has been studied. The (PdLCl2)-Cl-1 complex is more cytotoxic than L-1 ligand.

Kokina T.E. , Sheludyakova L.A. , Eremina Y.A. , Vorontsova E.V. , Glinskaya L.A. , Piryazev D.A. , Lider E.V. , Tkachev A.V. , Larionov S.V.
Complexes of Cu(I) and Pd(II) with (+)-Camphor and (-)-Cavrone Thiosemicarbazones: Synthesis, Structure, and Cytotoxicity of the Pd(II) Complex
Russian Journal of General Chemistry. 2017. V.87. N10. P.2332-2342. DOI: 10.1134/S1070363217100140 WOS Scopus РИНЦ

Кокина Т.Е. , Шелудякова Л.А. , Еремина Ю.А. , Воронцова Е.В. , Глинская Л.А. , Пирязев Д.А. , Лидер Е.В. , Ткачев А.В. , Ларионов С.В.
Комплексы cu(i) и pd(ii) с тиосемикарбазонами (+)-камфоры и (-)-карвона: синтез, строение и цитотоксичность комплекса Pd(II)
Журнал общей химии (RUSS J GEN CHEM+). 2017. Т.87. №10. С.1674-1684. РИНЦ

Published print:	Oct 1, 2017
Published online:	Nov 12, 2017

Web of science	WOS:000415280200014
Scopus	2-s2.0-85034572552
Elibrary	31049611
OpenAlex	W2767898927