Synthesis of pyrimidine and 1,3-bishydroxylamine derivatives from enone Mannich base methiodides

Synthesis of pyrimidine and 1,3-bishydroxylamine derivatives from enone Mannich base methiodides Full article

Journal

Heterocyclic Communications
ISSN: 0793-0283

Output data

Year: 2002, Volume: 8, Number: 3, Pages: 249-254 Pages count : 6 DOI: 10.1515/HC.2002.8.3.249

Authors

Khlestkin V.K. ¹ , Tikhonov A.Y. ¹

Affiliations

1	(Scopus) Novosibirsk Inst. of Organ. Chem., prosp. Lavrent'eva, 9, Novosibirsk 630090, Russian Federation

Reaction of the bis(aminomethylated) alkylaromatic ketones with methyl iodide gave the enone Mannich base methiodides. Subsequent reaction with two equivalents of methoxyamine or sodium anti-benzaldoximate resulted in 1,3-bismethoxyamine or dinitrone correspondingly. Partial hydroxylaminolyses of dinitrones led to 5-aroyl-1,3-dihydroxy-2-phenylperhydropyrimidines. Reaction of the enone Mannich base methiodides with cyclic paramagnetic amidine gave nitroxides of imidazopyrimidine series.

Khlestkin V.K. , Tikhonov A.Y.
Synthesis of pyrimidine and 1,3-bishydroxylamine derivatives from enone Mannich base methiodides
Heterocyclic Communications. 2002. V.8. N3. P.249-254. DOI: 10.1515/HC.2002.8.3.249 WOS Scopus РИНЦ

Published print:

Jan 1, 2002

Web of science	WOS:000177803900007
Scopus	2-s2.0-0036025098
Elibrary	13406403
OpenAlex	W2321848035