The toxic action of a new phenolic antioxidant SO-3 studied in a subchronic experiment

The toxic action of a new phenolic antioxidant SO-3 studied in a subchronic experiment Full article

Journal

Экспериментальная и клиническая фармакология/Eksperimental'naya i Klinicheskaya Farmakologiya
ISSN: 0869-2092

Output data

Year: 2000, Volume: 63, Number: 4, Pages: 60- Pages count :

Authors

Voevoda T.V. ¹ , Tolstikova T.G. ¹ , Sorokina I.V. ¹ , Dolgikh M.P. ¹ , Orlova T.N. ¹

Affiliations

1	(Scopus) Vorozhtsov Inst. of Organ. Chemistry, Siberian Division, Russian Academy of Sciences, pr. Akad. Lavrent'eva 9, Novosibirsk, 630090, Russian Federation

Subchronic tests on rats showed that a new phenolic antioxidant bis[3,(3, 5-di-tert-butyl-4-hydroxyphenyl)propyl] sulfide (SO-3) exhibits low toxicity upon peroral administration. Neither significant variations in the hematological and integral indices, nor pathological shifts in the activity of serum enzymes or pathomorphological changes in the internal organs were observed. Simultaneous administration of a sunflower oil with SO-3 led to a significant decrease in the blood cholesterol level, produced a hepatoprotector effect, and exhibited a protective action with respect to the mucous membranes of the gastrointestinal tract. Animals receiving large doses of SO-3 showed no signs of a prelipid stage of the arteriosclerosis typically observed in the control group.

Voevoda T.V. , Tolstikova T.G. , Sorokina I.V. , Dolgikh M.P. , Orlova T.N.
The toxic action of a new phenolic antioxidant SO-3 studied in a subchronic experiment
Экспериментальная и клиническая фармакология/Eksperimental'naya i Klinicheskaya Farmakologiya. 2000. V.63. N4. P.60-. Scopus РИНЦ

Scopus	2-s2.0-0042185626
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