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Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells Full article

Journal Molecular Biology
ISSN: 0026-8933
Output data Year: 2017, Volume: 51, Number: 5, Pages: 705-711 Pages count : DOI: 10.1134/S0026893317050090
Tags ursolic acid; pomolic acid; selective cytotoxicity; glioma; apoptosis
Authors Frolova T. S. 1,2,3 , Lipeeva A. V. 1 , Baev D. S. 1,3 , Tsepilov Y. A. 2,3 , Sinitsyna O. I. 2,3
Affiliations
1 (Данные Web of science) Russian Acad Sci, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2 (Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
3 (Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

Abstract: Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.
Cite: Frolova T.S. , Lipeeva A.V. , Baev D.S. , Tsepilov Y.A. , Sinitsyna O.I.
Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells
Molecular Biology. 2017. V.51. N5. P.705-711. DOI: 10.1134/S0026893317050090 WOS Scopus РИНЦ
Dates:
Published print: Sep 1, 2017
Published online: Oct 13, 2017
Identifiers:
Web of science WOS:000412903500007
Scopus 2-s2.0-85031414336
Elibrary 31068927
OpenAlex W2763582089
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