Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0(2,6).0(8,10)]Dodec-11-EN-4-YL)Ureas

Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0(2,6).0(8,10)]Dodec-11-EN-4-YL)Ureas Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031

Output data

Year: 2017, Volume: 51, Number: 6, Pages: 439-443 Pages count : 5 DOI: 10.1007/s11094-017-1629-9

Tags

arylisocyanates; arylisothiocyanates; 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-en-4-yl)ureas; smallpox vaccines; antiviral activity; pharmacological activity

Authors

Selivanov B.A. ¹ , Tikhonov A.Ya. ¹ , Belanov E.F. ² , Bormotov N.I. ² , Kabanov A.S. ² , Mazurkov O.Yu. ² , Serova O.A. ² , Shishkina L.N. ² , Agafonov A.P. ² , Sergeev A.N. ²

Affiliations

1	(Данные Web of science) Russian Acad Sci NIOCh SB RAS, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, 9 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia
2	(Данные Web of science) VECTOR State Res Ctr Virol & Biotechnol, Koltsov 630559, Novosibirsk Obl, Russia

A series of 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-en-4-yl)urea derivatives were synthesized and studied for antiviral activity against smallpox vaccine virus. 3-(3,5-Dioxo-4-azatetracyclo-[5.3.2.0(2,6).0(8,10)]dodec-11-en-4-yl)-1-(4-methylphenyl)urea, 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-en-4-yl)-1-(3-fluorophenyl)urea hydrate, and 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-en-4-yl)-1-(phenyl)thiourea showed pronounced activity.

Selivanov B.A. , Tikhonov A.Y. , Belanov E.F. , Bormotov N.I. , Kabanov A.S. , Mazurkov O.Y. , Serova O.A. , Shishkina L.N. , Agafonov A.P. , Sergeev A.N.
Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0(2,6).0(8,10)]Dodec-11-EN-4-YL)Ureas
Pharmaceutical Chemistry Journal. 2017. V.51. N6. P.439-443. DOI: 10.1007/s11094-017-1629-9 WOS Scopus РИНЦ

Селиванов Б.А. , Тихонов А.Я. , Беланов Е.Ф. , Бормотов Н.И. , Кабанов А.С. , Мазурков О.Ю. , Серова О.А. , Скурат Л.Н. , Агафонов А.П. , Сергеев А.Н.
Синтез и противовирусная активность 1-арил-3-{3,5-диоксо-4-азатетрацикло-[5.3.2.02,6.08,10]додец-11-ен-4-ил}мочевин
Химико-фармацевтический журнал (PHARM CHEM J+). 2017. Т.51. №6. С.13-17. РИНЦ

Published print:	Sep 1, 2017
Published online:	Oct 10, 2017

Web of science	WOS:000413302000003
Scopus	2-s2.0-85030854888
Elibrary	31058565
OpenAlex	W2762573356