Fluorine-Containing n-6 and Angular and Linear n-6-n' (n, n'=5, 6, 7) Diaza-Heterocyclic Scaffolds Assembled on Benzene Core in Unified Way

Fluorine-Containing n-6 and Angular and Linear n-6-n' (n, n'=5, 6, 7) Diaza-Heterocyclic Scaffolds Assembled on Benzene Core in Unified Way Full article

Journal

ChemistrySelect
ISSN: 2365-6549

Output data

Year: 2019, Volume: 4, Number: 8, Pages: 2383-2386 Pages count : 4 DOI: 10.1002/slct.201803970

Tags

benzo-fused heterocycles; boron heterocycles; fluoroaromatics; nitrogen heterocycles; structure elucidation; synthesis

Authors

Prima Darya O. ^1,2 , Makarov Arkady G. ¹ , Bagryanskaya Irina Yu ^1,3 , Kolesnikov Andrey E. ³ , Zargarova Leila, V ³ , Baev Dmitry S. ^1,3 , Eliseeva Tatiana F. ¹ , Politanskaya Larisa, V ^1,3 , Makarov Alexander Yu ¹ , Slizhov Yuri G. ² , Zibarev Andrey, V ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Organ Chem, Novosibirsk 630090, Russia
2	(Данные Web of science) Tomsk State Univ, Natl Res Univ, Dept Chem, Tomsk 634050, Russia
3	(Данные Web of science) Novosibirsk State Univ, Natl Res Univ, Dept Nat Sci, Novosibirsk 630090, Russia

The title compounds, including hybrids (n not equal n'), were assembled on benzene core in a unified way based on only one starting material C6F5NH2 and a limited number of simple substitution and condensation reactions. The heterocyclic moieties were 1,3-diazoles, 1,2,3-triazoles, 1,2,5-thia(selena)diazoles, 1.4-diazines and 1,5-diazepines, as well as 1,3,2-dioxaboroles. Representatives of all new scaffolds were characterized by XRD. Compounds synthesized are of biomedical interest in the context of apoptotic anticancer activity, and the 1,2,5-thiadiazole/1,3,2-dioxaborole hybrid also in that of neutron or/and proton capture therapy of cancer. New 1,2,5-chalcogenadiazoles are protected forms of otherwise hardly accessible fluorine-containing di- and tetra-amines for further syntheses.

Prima D.O. , Makarov A.G. , Bagryanskaya I.Y. , Kolesnikov A.E. , Zargarova L.V. , Baev D.S. , Eliseeva T.F. , Politanskaya L.V. , Makarov A.Y. , Slizhov Y.G. , Zibarev A.V.
Fluorine-Containing n-6 and Angular and Linear n-6-n' (n, n'=5, 6, 7) Diaza-Heterocyclic Scaffolds Assembled on Benzene Core in Unified Way
ChemistrySelect. 2019. V.4. N8. P.2383-2386. DOI: 10.1002/slct.201803970 WOS Scopus РИНЦ

Published online:	Feb 27, 2019
Published print:	Feb 28, 2019

Web of science	WOS:000459929100022
Scopus	2-s2.0-85062221121
Elibrary	38694250
OpenAlex	W2919138888