Effect of the synthetic resorcinol derivative of caryophyllene on cholesterol biosynthesis and the functional activity of immune system cells

Effect of the synthetic resorcinol derivative of caryophyllene on cholesterol biosynthesis and the functional activity of immune system cells Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031

Output data

Year: 2006, Volume: 40, Number: 10, Pages: 540-543 Pages count : 4 DOI: 10.1007/s11094-006-0188-2

Authors

Kudinova E.N. ¹ , Salakhutdinov N.F. ² , Fomenko V.V. ² , Vol'skii N.N. ³ , Perminova O.M. ³ , Khoshchenko O.N. ¹ , Shwarts Y.Ch. ¹ , Dushkin M.I. ¹

Affiliations

1	(Scopus) Institute of Internal Medicine, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk, Russian Federation
2	(Scopus) Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russian Federation
3	(Scopus) Institute of Clinical Immunology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

The synthesis of a water-soluble compound belonging to the group of terpenoids-disodium salt of a resorcinol derivative of caryophyllene-is described. The biological properties of the new compound have been studied in mice in comparison to some native terpenoids and atorvastatin. The synthesized terpenoid (5 mg/mouse) decreases the rate of cholesterol biosynthesis in murine liver. Similar effects were observed for atorvastatin (0.2 mg/mouse) and the native terpenoids (8.5 mg/mouse), except for perillic alcohol (which produced a stimulating action). In addition, the obtained resorcinol derivative of caryophyllene inhibits mitogen-stimulated murine splenic cell proliferation in vitro in a dose-dependent manner. The drug efficacy in this reaction is comparable with that of perillic alcohol and α-terpineol, while being less pronounced than the effect of dipentene and atorvastatin. © 2006 Springer Science+Business Media, Inc.

Kudinova E.N. , Salakhutdinov N.F. , Fomenko V.V. , Vol'skii N.N. , Perminova O.M. , Khoshchenko O.N. , Shwarts Y.C. , Dushkin M.I.
Effect of the synthetic resorcinol derivative of caryophyllene on cholesterol biosynthesis and the functional activity of immune system cells
Pharmaceutical Chemistry Journal. 2006. V.40. N10. P.540-543. DOI: 10.1007/s11094-006-0188-2 Scopus РИНЦ

Кудинова Е.Н. , Салахутдинов Н.Ф. , Фоменко В.В. , Вольский Н.Н. , Перминова О.М. , Хощенко О.Н. , Шварц Я.Ш. , Душкин М.И.
Влияние синтетического производного резорцина кариофиллена на биосинтез холестерина и на функциональную активность клеток иммунной системы
Химико-фармацевтический журнал (PHARM CHEM J+). 2006. Т.40. №10. С.20-23. РИНЦ

Published print:

Oct 1, 2006

Scopus	2-s2.0-34147191024
Elibrary	13512809
OpenAlex	W2030190766