Synthesis of 2H-benzimidazole 1,3-dioxides, separase inhibitors, by reaction of o-benzoquinone dioximes with ketones

Synthesis of 2H-benzimidazole 1,3-dioxides, separase inhibitors, by reaction of o-benzoquinone dioximes with ketones Full article

Journal

Tetrahedron
ISSN: 0040-4020

Output data

Year: 2017, Volume: 73, Number: 27-28, Pages: 3986-3992 Pages count : 7 DOI: 10.1016/j.tet.2017.05.078

Tags

2H-benzimidazole 1,3-dioxide; o-Benzoquinone dioxime; Ketone; Nitration; Separase inhibitor

Authors

Chugunova Elena ^1,2 , Samsonov Vladimir ³ , Akylbekov Nurgali ⁴ , Mazhukin Dmitrii ^3,5

Affiliations

1	(Данные Web of science) Russian Acad Sci, AE Arbuzov Inst Organ & Phys Chem, Kazan Sci Ctr, 8 Arbuzov St, Kazan 420088, Russia
2	(Данные Web of science) Kazan Fed Univ, 18 Kremlyovskaya St, Kazan 420008, Russia
3	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Akad Lavrentreva, Novosibirsk 630090, Russia
4	(Данные Web of science) Kazan Natl Res Technol Univ, 68 Karl Marx St, Kazan 420015, Russia
5	(Данные Web of science) Novosibirsk State Univ, 2 Pirogova St, Novosibirsk 630090, Russia

The synthesis of novel 2H-benzimidazole 1,3-dioxides on the basis of o-benzoquinone dioximes interaction with ketones in the presence of acids is described. Nitration of these compounds by nitric acid in acetic acid yields the 5-nitro derivatives of 2H-benzimidazole 1,3-dioxide. (C) 2017 Elsevier Ltd. All rights reserved.

Chugunova E. , Samsonov V. , Akylbekov N. , Mazhukin D.
Synthesis of 2H-benzimidazole 1,3-dioxides, separase inhibitors, by reaction of o-benzoquinone dioximes with ketones
Tetrahedron. 2017. V.73. N27-28. P.3986-3992. DOI: 10.1016/j.tet.2017.05.078 WOS Scopus РИНЦ

Published print:

Jul 1, 2017

Web of science	WOS:000403998200024
Scopus	2-s2.0-85019708401
Elibrary	31037667
OpenAlex	W2620078510