Synthesis of camphecene derivatives using click chemistry methodology and study of their antiviral activity

Synthesis of camphecene derivatives using click chemistry methodology and study of their antiviral activity Full article

Journal

Bioorganic and Medicinal Chemistry Letters
ISSN: 0960-894X , E-ISSN: 1464-3405

Output data

Year: 2017, Volume: 27, Number: 10, Pages: 2181-2184 Pages count : 4 DOI: 10.1016/j.bmcl.2017.03.051

Tags

Acetylenes; Antivirals; Azides; Camphor; Click chemistry; Imine derivatives; Influenza; Triazoles

Authors

Artyushin Oleg I. ¹ , Sharova Elena V. ¹ , Vinogradova Natalya M. ¹ , Genkina Galina K. ¹ , Moiseeva Aleksandra A. ¹ , Klemenkova Zinaida S. ¹ , Orshanskaya Iana R. ² , Shtro Anna A. ² , Kadyrova Renata A. ² , Zarubaev Vladimir V. ² , Yarovaya Olga I. ^3,4 , Salakhutdinov Nariman F. ^3,4 , Brel Valery K. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28 Vavilova St,GSP-1,V-334, Moscow 119991, Russia
2	(Данные Web of science) Influenza Res Inst, Dept Chemotherapy, 15-17 Prof Popova St, St Petersburg 197376, Russia
3	(Данные Web of science) Russian Acad Sci, Siberian Branch, Novosibirsk Inst Organ Chem, Lavrentjev Ave 9, Novosibirsk 630090, Russia
4	(Данные Web of science) Novosibirsk State Univ, Pirogova St 2, Novosibirsk 630090, Russia

A series of seventeen tetrazole derivatives of 1,7,7-trimethyl-[2.2.1]bicycloheptane were synthesized using click chemistry methodology and characterized by spectral data. Studies of cytotoxicity and in vitro antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1) in MDCK cells of the compounds obtained were performed. The structure-activity relationship analysis suggests that to possess virus-inhibiting activity, the compounds of this group should bear oxygen atom with a short linker (C2-C4), either as a hydroxyl group (18, 19, 29), keto-group (21) or as a part of a heterocycle (24). These compounds demonstrated low cytotoxicity along with high anti-viral activity. (C) 2017 Published by Elsevier Ltd.

Artyushin O.I. , Sharova E.V. , Vinogradova N.M. , Genkina G.K. , Moiseeva A.A. , Klemenkova Z.S. , Orshanskaya I.R. , Shtro A.A. , Kadyrova R.A. , Zarubaev V.V. , Yarovaya O.I. , Salakhutdinov N.F. , Brel V.K.
Synthesis of camphecene derivatives using click chemistry methodology and study of their antiviral activity
Bioorganic and Medicinal Chemistry Letters. 2017. V.27. N10. P.2181-2184. DOI: 10.1016/j.bmcl.2017.03.051 WOS Scopus РИНЦ

Published print:

May 1, 2017

Web of science	WOS:000401492500021
Scopus	2-s2.0-85016578082
Elibrary	29482366
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