Genotoxicological safety assessment of a new antiparkinsonian substance ((1r,2r,6s)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol)

Genotoxicological safety assessment of a new antiparkinsonian substance ((1r,2r,6s)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol) Full article

Journal

World Journal of Medical Sciences
ISSN: 1817-3055

Output data

Year: 2013, Volume: 8, Number: 4, Pages: 355-358 Pages count : 4 DOI: 10.5829/idosi.wjms.2013.8.4.1123

Tags

Diol; Genotoxicological safety; Mutations; Parkinson's disease; Treatment

Authors

Trushin M.V. ¹ , Ardashov O.V. ² , Volcho K.P. ² , Arkharova I.A. ² , Salakhutdinov N.F. ²

Affiliations

1	(Scopus) Kazan Federal University, Kazan, Russian Federation
2	(Scopus) Vorozhtsov Novosibirsk Institute of Organic Chemistry, Russian Academy of Sciences, Novosibirsk, Russian Federation

Parkinson's disease (PD) is a neurodegenerative condition of unknown etiology. This article is devoted to special genotoxicological testing of a new substance with antiparkinsonian activity. It was assessed using Allium cepa-test system. As a result of study of the effect (1R, 2R, 6S)-3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol in cell model object (Allium cepa) we revealed two distinctive features of the effects of substance-itotoxic effect and no increase in the frequency of genetic disorders with increasing concentration of the substance. In general, the tested substance seems safe. © IDOSI Publications, 2013.

Trushin M.V. , Ardashov O.V. , Volcho K.P. , Arkharova I.A. , Salakhutdinov N.F.
Genotoxicological safety assessment of a new antiparkinsonian substance ((1r,2r,6s)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol)
World Journal of Medical Sciences. 2013. V.8. N4. P.355-358. DOI: 10.5829/idosi.wjms.2013.8.4.1123 Scopus РИНЦ

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