Lappaconitine: Influence of halogen substituent on the antiarrhythmic activity

Lappaconitine: Influence of halogen substituent on the antiarrhythmic activity Full article

Journal

Cardiovascular and Hematological Agents in Medicinal Chemistry
ISSN: 1871-5257

Output data

Year: 2013, Volume: 11, Number: 3, Pages: 211-217 Pages count : DOI: 10.2174/18715257113119990083

Tags

Arrhythmia; Halogen-containing lappaconitine derivatives; Lappaconitine

Authors

Bryzgalov A. O. , Romanov V. E. , Tolstikova T. G. , Shults E. E.

Affiliations

1	(Scopus) Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Prosp. Akad. Lavrent'eva, 630090 Novosibirsk, Russian Federation

The current paper presents research results related to antiarrhythmic activity of halogen-containing derivatives of lappaconitine. Lappaconitine derivatives with iodine, chlorine or bromine substituting the anthranilate moiety at C-5' position were shown in vivo and in vitro to exhibit a more (Br, I) or less (Cl) pronounced antiarrhythmic activity in the models of calcium chloride- and adrenaline-induced arrhythmias as compared with the reference compound lappaconitine. The intensity of antiarrhythmic action depending on halogen substituent was found to be expressed by the following order: Cl < I < Br. © 2013 Bentham Science Publishers.

Bryzgalov A.O. , Romanov V.E. , Tolstikova T.G. , Shults E.E.
Lappaconitine: Influence of halogen substituent on the antiarrhythmic activity
Cardiovascular and Hematological Agents in Medicinal Chemistry. 2013. V.11. N3. P.211-217. DOI: 10.2174/18715257113119990083 Scopus РИНЦ

Published print:

Jan 31, 2014

Scopus	2-s2.0-84892958801
Elibrary	21909441
OpenAlex	W2063757150