Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid

Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2017, Volume: 53, Number: 1, Pages: 77-82 Pages count : 6 DOI: 10.1007/s10600-017-1915-5

Tags

1,2,3-triazoles; Cytotoxicity; Dialkynyllabdadienes; Lambertianic acid; Macroheterocycles

Authors

Kharitonov Y.V. ^1,2 , Shakirov M.M. ¹ , Pokrovskii M.A. ² , Pokrovskii A.G. ² , Shu?Ts E.E. ^1,2

Affiliations

1	(Scopus) N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 9 Prosp. Akad. Lavren?eva, Novosibirsk, 630090, Russian Federation
2	(Scopus) Novosibirsk National Research State University, 2 Pirogova St, Novosibirsk, 630090, Russian Federation

(17R)-17,18-Dipropargyloxylabda-13,15-diene was synthesized and underwent Cu-catalyzed cycloaddition with 1,10-diazodecane or 1,2-bis(2-azidoethoxy)ethane to produce macroheterocycles of the furanolabdanoid decalin fragment. The macroheterocyclic labdanoids showed significant cytotoxicity in MEL-8, MT-4, and U-937 human tumor cell models. © 2017 Springer Science+Business Media New York.

Kharitonov Y.V. , Shakirov M.M. , Pokrovskii M.A. , Pokrovskii A.G. , Shu?Ts E.E.
Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid
Chemistry of Natural Compounds. 2017. V.53. N1. P.77-82. DOI: 10.1007/s10600-017-1915-5 WOS Scopus РИНЦ

Published print:	Jan 1, 2017
Published online:	Feb 22, 2017

Web of science	WOS:000395066000019
Scopus	2-s2.0-85013421857
Elibrary	31032002
OpenAlex	W2590277694