Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration

Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration Full article

Journal

Scientific Reports
ISSN: 2045-2322

Output data

Year: 2019, Volume: 9, Number: 1, Article number : 12093, Pages count : DOI: 10.1038/s41598-019-48524-3

Authors

Gorodetskii A.A. ^1,2,3,4 , Eubank T.D. ^1,5,6 , Driesschaert B. ^1,6,7 , Poncelet M. ^1,7 , Ellis E. ⁵ , Khramtsov V.V. ^1,2,6 , Bobko A.A. ^1,2,6

Affiliations

1	(Scopus) In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, United States
2	(Scopus) Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506, United States
3	(Scopus) N.N. Voroztsov Novosibirsk Institute of Organic Chemistry SB RAS, Novosibirsk, 630090, Russian Federation
4	(Scopus) Novosibirsk State University, Novosibirsk, 630090, Russian Federation
5	(Scopus) Department of Microbiology, Immunology & Cell Biology, West Virginia University School of Medicine, Morgantown, WV 26506, United States
6	(Scopus) Department of Pharmaceutical Sciences, West Virginia University, School of Pharmacy, Morgantown, WV 26506, United States
7	(Scopus) West Virginia University Cancer Institute, Morgantown, WV 26506, United States

Tumor oxygenation (pO2), acidosis (pH) and interstitial inorganic phosphate concentration (Pi) are important parameters of the malignant behavior of cancer. A noninvasive procedure that enables visualization of these parameters may provide unique information about mechanisms of tumor pathophysiology and provide clues to new treatment targets. In this research, we present a multiparametric imaging method allowing for concurrent mapping of pH, spin probe concentration, pO2, and Pi using a single contrast agent and Overhauser-enhanced magnetic resonance imaging technique. The developed approach was applied to concurrent multifunctional imaging in phantom samples and in vivo in a mouse model of breast cancer. Tumor tissues showed higher heterogeneity of the distributions of the parameters compared with normal mammary gland and demonstrated the areas of significant acidosis, hypoxia, and elevated Pi content. © 2019, The Author(s).

Gorodetskii A.A. , Eubank T.D. , Driesschaert B. , Poncelet M. , Ellis E. , Khramtsov V.V. , Bobko A.A.
Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration

Scientific Reports. 2019. V.9. N1. 12093 . DOI: 10.1038/s41598-019-48524-3 WOS Scopus РИНЦ

Full text from publisher

Published online:	Aug 20, 2019
Published print:	Dec 1, 2019

Web of science	WOS:000481745900004
Scopus	2-s2.0-85070819729
Elibrary	41616781
OpenAlex	W2969724717