Morphological Assessment of Prostatotropic Activity of (3,5-Dimethyl-4-Hydroxy)Benzyl Thiododecane on a Model of Benign Prostatic Hyperplasia in Rats

Morphological Assessment of Prostatotropic Activity of (3,5-Dimethyl-4-Hydroxy)Benzyl Thiododecane on a Model of Benign Prostatic Hyperplasia in Rats Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2019, Volume: 167, Number: 6, Pages: 809-812 Pages count : 4 DOI: 10.1007/s10517-019-04628-4

Tags

benign prostatic hyperplasia; benzyl thiododecane; morphology; Permixon; sulpiride

Authors

Nizomov S.A. ¹ , Sorokina I.V. ¹ , Zhukova N.A. ¹ , Tolstikova T.G. ¹ , Semenov D.E. ² , Prosenko A.E. ³

Affiliations

1	(Scopus) N. N. Vorozhtsov Novosibirsk Institute of Organic and Physical Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation
2	(Scopus) Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russian Federation
3	(Scopus) Novosibirsk State Pedagogical University, Novosibirsk, Russian Federation

Prostatotropic activity of (3,5-dimethyl-4-hydroxy)benzyl thiododecane (T-DD) was evaluated on a model of benign prostatic hyperplasia induced in Wistar rats by chronic (2 months) intraperitoneal administration of sulpiride (40 mg/kg). Morphometric analysis of the dorsolateral lobe of the prostate showed that after the 2-month course of intragastric T-DD (100 mg/kg) administered in parallel with sulpiride, the volume density of glandular epithelium decreased by 1.7 times, while the volume density of prostate stroma increased by 2 times. After administration of the reference drug Permixon at a dose of 50 mg/kg, the volume densities of epithelium decreased by 1.3 times and stromal volume density increased by 1.5 times. The observed effects are presumably related to suppression of 5α-reductase activity and modulation of estrogen receptors in the prostate. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Nizomov S.A. , Sorokina I.V. , Zhukova N.A. , Tolstikova T.G. , Semenov D.E. , Prosenko A.E.
Morphological Assessment of Prostatotropic Activity of (3,5-Dimethyl-4-Hydroxy)Benzyl Thiododecane on a Model of Benign Prostatic Hyperplasia in Rats
Bulletin of Experimental Biology and Medicine. 2019. V.167. N6. P.809-812. DOI: 10.1007/s10517-019-04628-4 WOS Scopus РИНЦ

Низомов С.А. , Сорокина И.В. , Жукова Н.А. , Толстикова Т.Г. , Семенов Д.Е. , Просенко А.Е.
Морфологическая оценка простатотропной активности (3,5-диметил-4-гидрокси)бензилтиододекана на модели доброкачественной гиперплазии предстательной железы у крыс
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2019. Т.167. №6. С.772-776. РИНЦ

Низомов С.А. , Сорокина И.В. , Жукова Н.А. , Толстикова Т.Г. , Семенов Д.Е. , Просенко А.Е.
Сравнительное исследование токсичности алкоксиаминов in vitro и in vivo
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2017. Т.164. №7. С.61-65. РИНЦ

Published print:	Oct 1, 2019
Published online:	Oct 26, 2019

Web of science	WOS:000492659600008
Scopus	2-s2.0-85074764151
Elibrary	41698064
OpenAlex	W2981418044