Long-wavelength photoremovable protecting groups: On the way to in vivo application

Long-wavelength photoremovable protecting groups: On the way to in vivo application Full article

Journal

Computational and Structural Biotechnology Journal
ISSN: 2001-0370

Output data

Year: 2020, Volume: 18, Pages: 27-34 Pages count : 8 DOI: 10.1016/j.csbj.2019.11.007

Tags

caged compounds; long-wavelength excitation; photoremovable protecting groups

Authors

Vorobev A.Yu. ^1,2 , Moskalensky A.E. ^2,3

Affiliations

1	(Scopus) N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 9 Lavrentiev Ave., Novosibirsk, 630090, Russian Federation
2	(Scopus) Novosibirsk State University, Pirogova 2, Novosibirsk, 630090, Russian Federation
3	(Scopus) Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, Institutskaya str. 3, Novosibirsk, 630090, Russian Federation

Photoremovable protective groups (PPGs) and related “caged” compounds have been recognized as a powerful tool in an arsenal of life science methods. The present review is focused on recent advances in design of “caged” compounds which function in red or near-infrared region. The naive comparison of photon energy with that of organic bond leads to the illusion that long-wavelength activation is possible only for weak chemical bonds like N-N. However, there are different means to overcome this threshold and shift the uncaging functionality into red or near-infrared regions for general organic bonds. We overview these strategies, including the novel photochemical and photophysical mechanisms used in newly developed PPGs, singlet-oxygen-mediated photolysis, and two-photon absorption. Recent advances in science places the infrared-sensitive PPGs to the same usability level as traditional ones, facilitating in vivo application of caged compounds. © 2019 The Authors

Vorobev A.Y. , Moskalensky A.E.
Long-wavelength photoremovable protecting groups: On the way to in vivo application

Computational and Structural Biotechnology Journal. 2020. V.18. P.27-34. DOI: 10.1016/j.csbj.2019.11.007 WOS Scopus РИНЦ

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Web of science	WOS:000607305900004
Scopus	2-s2.0-85076046047
Elibrary	43210596
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