Synthesis of 3-Fluoropyrazolo[1,5-A]Pyridines by Fluorination of Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylates

Synthesis of 3-Fluoropyrazolo[1,5-A]Pyridines by Fluorination of Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylates Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353

Output data

Year: 2020, Volume: 56, Number: 7, Pages: 957-960 Pages count : 4 DOI: 10.1007/s10593-020-02757-7

Tags

electrophilic fluorination; pyrazolo[1,5-a]pyridines; Selectfluor

Authors

Alieva Sabina V. ^1,2 , Vorob’ev Aleksey Yu. ¹

Affiliations

1	(Scopus) N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave, Novosibirsk, 630090, Russian Federation
2	(Scopus) Novosibirsk State University, 1 Pirogova St, Novosibirsk, 630090, Russian Federation

[Figure not available: see fulltext.] The reaction of methyl esters of pyrazolo[1,5-a]pyridine-2,3-dicarboxylic and 2-phenylpyrazolo[1,5-a]pyridine-3-carboxylic acids with the fluorinating reagent Selectfluor gave 3-fluoropyrazolo[1,5-a]pyridine-2-carboxylic acid methyl ester and 3-fluoro-2-phenylpyrazolo- [1,5-a]pyridine. Monitoring the progress of the reaction by 1H NMR spectroscopy showed the formation of an intermediate fluorinecontaining σ-complex. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Alieva S.V. , Vorob’ev A.Y.
Synthesis of 3-Fluoropyrazolo[1,5-A]Pyridines by Fluorination of Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylates
Chemistry of Heterocyclic Compounds. 2020. V.56. N7. P.957-960. DOI: 10.1007/s10593-020-02757-7 WOS Scopus РИНЦ

Published print:	Jul 1, 2020
Published online:	Aug 21, 2020

Web of science	WOS:000561986600004
Scopus	2-s2.0-85089751387
Elibrary	45375289
OpenAlex	W3080489066