The comparative immunotropic activity of carrageenan, chitosan and their complexes

The comparative immunotropic activity of carrageenan, chitosan and their complexes Full article

Journal

Marine Drugs
ISSN: 1660-3397

Output data

Year: 2020, Volume: 18, Number: 9, Article number : 458, Pages count : DOI: 10.3390/md18090458

Tags

Anti-inflammatory activity; Carrageenan; Chitosan; Cytokine; Nitric oxide; Polyelectrolyte complex

Authors

Davydova Viktoria N. ¹ , Sorokina Irina V. ² , Volo?ko Aleksandra V. ¹ , Sokolova Ekaterina V. ¹ , Borisova Marina S. ² , Yermak Irina M. ¹

Affiliations

1	G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 let Vladivostoku 159, 690022 Vladivostok, Russia
2	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentjev Ave. 9, 630090 Novosibirsk, Russia

The immunotropic activity of polyelectrolyte complexes (PEC) of κ-carrageenan (κ-CGN) and chitosan (CH) of various compositions was assessed in comparison with the initial polysaccharides in comparable doses. For this, two soluble forms of PEC, with an excess of CH (CH:CGN mass ratios of 10:1) and with an excess of CGN (CH: CGN mass ratios of 1:10) were prepared. The ability of PEC to scavenge NO depended on the content of the κ-CGN in the PEC. The ability of the PEC to induce the synthesis of pro-inflammatory (tumor necrosis factor-α (TNF-α)) and anti-inflammatory (interleukine-10 (IL-10)) cytokines in peripheral blood mononuclear cell was determined by the activity of the initial κ-CGN, regardless of their composition. The anti-inflammatory activity of PEC and the initial compounds was studied using test of histamine-, concanavalin A-, and sheep erythrocyte immunization-induced inflammation in mice. The highest activity of PEC, as well as the initial polysaccharides κ-CGN and CH, was observed in a histamine-induced exudative inflammation, directly related to the activation of phagocytic cells, i.e., macrophages and neutrophils. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Davydova V.N. , Sorokina I.V. , Volo?ko A.V. , Sokolova E.V. , Borisova M.S. , Yermak I.M.
The comparative immunotropic activity of carrageenan, chitosan and their complexes

Marine Drugs. 2020. V.18. N9. 458 . DOI: 10.3390/md18090458 WOS Scopus РИНЦ

Full text from publisher

Published online:

Sep 4, 2020

Web of science	WOS:000580040500001
Scopus	2-s2.0-85090742908
Elibrary	45296101
OpenAlex	W3083623074